Optimization of Fluconazol Synthesis: An Important Azole Antifungal Drug
Bibliographic record
Abstract
Fluconazole is an azolic second-generation antifungal drug and is part of the National List of Essential Drugs (RENAME) of the Brazilian Ministry of Health. It is considered as first choice for the treatment of some opportunistic fungal infections and also applied in the AIDS treatment program as prophylactic therapy to avoid these infections. Due to the importance of fluconazole for the Brazilian Health System (SUS), it is strategic the domain of its obtaining process. Thus, improvements in the synthesis of this substance are also of special interest. In this work, many changes were proposed and carried out in the original fluconazole synthetic route, aiming to increase yield and using solvents and processes with a lower environmental impact. With these optimizations, the overall yield achieved was 53%, which is about 10 times higher than that of the original process.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".