Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa
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Abstract
OBJECTIVE: The authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes. METHOD: ) between anorexia nervosa and 159 other phenotypes. RESULTS: of anorexia nervosa was 0.20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability arises from common genetic variation. The authors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring a previously reported type 1 diabetes and autoimmune disorder locus. Significant positive genetic correlations were observed between anorexia nervosa and schizophrenia, neuroticism, educational attainment, and high-density lipoprotein cholesterol, and significant negative genetic correlations were observed between anorexia nervosa and body mass index, insulin, glucose, and lipid phenotypes. CONCLUSIONS: Anorexia nervosa is a complex heritable phenotype for which this study has uncovered the first genome-wide significant locus. Anorexia nervosa also has large and significant genetic correlations with both psychiatric phenotypes and metabolic traits. The study results encourage a reconceptualization of this frequently lethal disorder as one with both psychiatric and metabolic etiology.
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The record
- Venue
- American Journal of Psychiatry
- Topic
- Eating Disorders and Behaviors
- Field
- Psychology
- Canadian institutions
- —
- Funders
- National Institute of Diabetes and Digestive and Kidney DiseasesNational Human Genome Research InstituteNational Institute on Alcohol Abuse and AlcoholismInstituto de Salud Carlos IIIKorea Centers for Disease Control and PreventionNational Health and Medical Research CouncilMenzies Centre for Australian Studies, King's College London, University of LondonMedical Research CouncilCanadian Institutes of Health ResearchSchool of Medicine, University of North Carolina at Chapel HillNational Institutes of HealthRegione del VenetoInstitut National de la Recherche AgronomiqueHorizon 2020 Framework ProgrammeVetenskapsrådetGenesis PharmaUniversity of TorontoGeneralitat de CatalunyaChina Scholarship CouncilMinisterio de Economía y CompetitividadBundesministerium für Bildung und ForschungBergens ForskningsstiftelseLouis and Harold Price FoundationUniversitetet i BergenNational Institute of Mental HealthEesti TeadusagentuurDeutsche ForschungsgemeinschaftNederlandse Organisatie voor Wetenschappelijk OnderzoekFlinders UniversityGovernment of OntarioInstitut National de la Santé et de la Recherche MédicaleMinisterstvo Zdravotnictví Ceské RepublikyAstraZenecaEkstraStiftelsen Helse og Rehabilitering (Stiftelsen Dam)European CommissionZonMwUniversity of CambridgeBroad InstituteNIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer ResearchSanofiSouth London and Maudsley NHS Foundation TrustBristol-Myers SquibbWellcome TrustLundbeckfondenEli Lilly and CompanyGenome CanadaAgència de Gestió d'Ajuts Universitaris i de RecercaNational Institute for Health and Care ResearchNHS Blood and TransplantUniversity of OtagoUniversity of CaliforniaH. Lundbeck A/SKlarman Family FoundationNorges ForskningsrådSchweizerische Anorexia Nervosa StiftungAlexander von Humboldt-StiftungAarhus UniversitetMassachusetts General HospitalGlaxoSmithKlinePfizerEuropean Regional Development FundKing's College LondonChildren's Hospital of PhiladelphiaCenters for Disease Control and PreventionNational Alliance for Research on Schizophrenia and DepressionNational and Kapodistrian University of AthensKarolinska Institutet
- Keywords
- Anorexia nervosaGenome-wide association studyLocus (genetics)Association (psychology)GeneticsGenetic associationPsychologyBiologyClinical psychologySingle-nucleotide polymorphismEating disordersGenotypeGenePsychotherapist
- Has abstract in OpenAlex
- yes