The Era for High-Sensitivity Cardiac Troponin Has Begun in the US (Finally)
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
On January 19, 2017, the Food and Drug Administration (FDA)3 announced the clearance of Roche Diagnostics Gen 5 STAT cardiac troponin T assay in the US (1). This is the first of what is likely to be many next-generation or perhaps high-sensitivity (hs) cardiac troponin (cTn) assays released in the next few years. The Roche Diagnostics Gen 5 assay has been available in Europe, Asia, Australia, and Canada for 7 years. The 99th percentile cutoff limit has been changed from <0.010 ng/mL (10 ng/L) for the 4th generation cardiac troponin T (cTnT) assay to sex-specific cutoffs of 14 ng/L (0.014 ng/mL) for women, 22 ng/L (0.022 ng/mL) for men, and 19 ng/L (0.019 ng/mL) for both sexes for the 5th generation. (Note: a value of 10 ng/L with the 4th generation assay will read closer to 30 ng/L with the 5th generation assay.) As with assays for other analytes, each hospital may need to establish their own sex-specific cutoffs based on their study population. …
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.014 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it