Acute exacerbations of idiopathic pulmonary fibrosis: tough to define; tougher to manage
Bibliographic record
Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic, often fatal fibrotic lung disease that typically affects adults over the age of 60 [1]. The disease is characterised by progressive fibrosis of the lung interstitium, which is associated with pronounced architectural distortion, a decline in lung volumes, and impaired gas exchange. The average survival from the time of diagnosis is between 3 and 5 years [2]. There is significant heterogeneity, however, among individual patients as the clinical course is both variable and unpredictable [3]. Some patients have a protracted course with little functional impairment. In others, periods of relative stability can be punctuated by an acute respiratory worsening, labelled as acute exacerbations of IPF that can precipitate dramatic respiratory failure [4]. Rarely, acute exacerbation of IPF is the initial manifestation of IPF leading to death within months. Nintedanib reduces the rate of acute exacerbation in IPF and may improve survival after an acute deterioration
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.006 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.001 | 0.003 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.012 | 0.011 |
| Insufficient payload (model declined to judge) | 0.005 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".