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Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one
Fabrizio De Benedetti, M. Gattorno, Helen Lachmann, Seza Özen, A. Simon, E. Ben-Chetrit, Y. Joubert, A. Speziale, Federica Penco, Alice Grossi, Maria Alessio, Giovanni Conti, Federico Marchetti, Alberto Tommasini, Romina Gallizzi, Annalisa Salis, Francesco Caroli, Gianluca Damonte, Carolina Uggenti, Lien Van Eyck, Isabelle Melki, Darragh Duffy, Vincent Bondet, Yoann Rose, Mathieu P. Rodero, Yvonne Kusche, Katarzyna Barczyk‐Kahlert, Annalisa Chiocchetti, Silvio Polizzi, Josef Vuch, Diego Vozzi, Anna Mondino, Erica Valencic, Serena Pastore, Flavio Faletra, Umberto Dianzani, Ugo Ramenghi, Qing Zhou, Xiaomin Yu, Natalie Deuitch, Deborah L. Stone, Wanxia Li Tsai, Amanda K. Ombrello, Tina Romeo, Elaine F. Remmers, JaeJin Chae, Massimo Gadina, Steven Welch, Rezan Topaloğlu, Mario Abinun, Ivona Aksentijevich, Donatella Vairo, Rosalba Monica Ferraro, Giulia Zani, Jessica Galli, Micaela De Simone, Elisa Fazzi, Silvia Giliani, Ebun Omoyinmi, Ariane Standing, Dorota Rowczenio, Annette Keylock, Sónia Gomes, Fiona Price-Kuehne, Sira Nanthapisal, Claire Murphy, Thomas Cullup, Lucy Jenkins, Kimberly Gilmour, Philip N. Hawkins, Nigel Klein, Paul Brogan, Anita Dhanrajani, Mercedes Chan, Stephanie Pau, Janet Ellsworth, Jaime Guzmán, Florence A. Aeschlimann, Marinka Twilt, Simon Eng, Shehla Sheikh, Ronald M. Laxer, Diane Hébert, Damien Noone, Christian Pagnoux, Susanne M. Benseler, Rae S. M. Yeung, Christoph Kessel, Katrin Lippitz, Toni Weinhage, Helmut Wittkowski, N.G. Grün, Pieter van Dijkhuizen, Federica Del Chierico, Clara Malattia, Alessandra Russo, Denise Pires Marafon, Silvia Magni‐Manzoni, Sebastiaan J. Vastert, Bruno Dallapiccola, Berent Prakken, Lorenza Putignani, Berna Eren Fidancı, Kenan Barut, Serap Arıcı, Doğan ŞİMŞEK, Mustafa Çakan, Ayşenur Kısaarslan, Ebru Yılmaz, Özge Başaran, Ferhat Demir, Kubra Ozturk, Zübeyde Gunduz, Betül Sözeri, Nuray Aktay Ayaz, Önder Yavaşcan, Özlem Aydoğ, Dilek Yıldız, Faysal Gök, Müferret Ergüven, Erbil Unsal, Özgür Kasapçopur, Erkan Demirkaya, Hafize Emine Sönmez, Yonatan Butbul, Yelda Bilginer, Claudia Bracaglia, Giusi Prencipe, G Lapeyre, Emiliano Marasco, Walter G. Ferlin, Robert D. Nelson, Cristina de Min, Nicolino Ruperto, T. Constantin, E. Alexeeva, K. Marzan, Nico Wulffraat, R. Schneider, Shai Padeh, V. Chasnyk, C. Wouters, J. B. Kuemmerle‐Deschner, T. Kallinich, E. Haddad, E. Nasonov, Olga Vougiouka, K. Leon, E. Vritzali, K. Lheritier, Francesca Schena, Claudia Pastorino, Francesca Kalli, Alessia Omenetti, Sabrina Chiesa, Paolo Picco, Gilberto Filaci, Elisabetta Traggiai, Marie‐Louise Frémond, Naoki Kitabayashi, Isabelle Meyts, Marie‐Anne Morren, Eric Legius, Isabelle Callebaut, Frédéric Rieux‐Laucat, Nadia Jeremiah, Alexandre Bélot, Éric Jeziorski, D. Bessis, Guilhem Cros, Gillian Rice, Bruno Charbit, Anne Hulin, Nihel Khoudour, Monique Fabrè, Laureline Berteloot, Muriel Le Bourgeois, Philippe Reix, Thierry Walzer, Despina Moshous, Stéphane Blanche, Alain Fischer, Kim V. Annink, Nienke M. ter Haar, Sulaiman M. Al‐Mayouf, Gayane Amaryan, Jordi Antón, KS Barron, L. Cantarini, Marco Cattalini, Alexis Virgil Cochino, F. Dedeoglu, A. De Jesus, O. Dellacasa, K. Durrant, Giovanna Fabio, Raphaela Goldbach‐Mansky, E. Hachulla, Véronique Hentgen, Troels Herlin, M. Hofer, Antonella Insalaco, Annette Jansson, Isabelle Koné‐Paut, Anastasiia Kozlova, Jasmin Kuemmerle‐Deschner, R. Laxer, Susan Nielsen, И. П. Никишина, Efimia Papadopoulou‐Alataki, Pierre Quartier, Angelo Ravelli, Donato Rigante, Ricardo Russo, Yosef Uziel, J. Frenkel, Jerold Jeyaratnam, Anna Simon, Matteo Doglio, Consuelo Modesto, Pierre Quartier, Esther P A H Hoppenreijs, Luca Cantarini, Inmaculada Calvo Penadés, Jana Pachlopnik Schmid, Thirusha Lane, Alberto Martini, Joost Frenkel, Chiara Passarelli, Elisa Pisaneschi, Virginia Messia, Antonio Novelli, J. B. Kuemmerle-Deschner, Xiaoyong Wei, Silvana Martino, Elisabetta Cortis, Angela Miniaci, Charlotte Eijkelboom, Pavla Doležalová, Isabelle Koné-Paut, Marija Jelušić, Liliana Bezrodnik, Mari Carmen Pinedo, Valda Staņēvicha, Mariëlle van Gijn, Silvia Federici, Hermann Girschick, Gerd Ganser, Christina Boros, Susanne Schalm, Marta De Marchi, Chiara Marini, Alberto Garaventa, Arinna Bertoni, Sonia Carta, Enrica Balza, Patrizia Castellani, C Pellecchia, Silvia Borghini, Maria Libera Trotta, Isabella Ceccherini, Anna Rubartelli, Andrew Henrey, Thomas M. Loughin, Roberta Berard, Natalie Shiff, Roman Juřenčák, Lori Tucker, Charalampia Papadopoulou, Petra Król, Hema Chaplin, Stephania Simou, Marietta Charakida, Despina Eleftheriou, Lynn Spiegel, Sara Ahola Kohut, Jennifer Stinson, Paula Forgeron, Miriam Kaufman, Nadia Luca, Khush Amaria, Mary Alice Bell, JF Swart, Fishman Boris, Elio Castagnola, Andreas H. Groll, Gabriella Giancane, G. Horneff, Tom F.W. Wolfs, Е.I. Alexeeva, V. Panaviene, Florence Uettwiller, M. Trachana, Laura Marinela Ailioaie, E. Tsitami, Sylvia Kamphuis, F. Sztajnbok, B. Flatø, Angela Pistorio, Stephanie Shoop-Worrall, Suzanne Verstappen, J. E. R. McDonagh, Kimme L Hyrich, Maarit Tarkiainen, Pirjo Tynjälä, Pekka Lahdenne, Janne Martikainen, Meredyth Wilkinson, Christopher Piper, Georg Otto, Claire T. Deakin, Stefanie Dowle, Stefania Simou, Daniel Kelberman, Claudia Mauri, Elizabeth C. Jury, David Isenberg, Lucy R. Wedderburn, Kiran Nistala, Ivan Foeldvari, Daniel J. Lovell, Gabriele Simonini, Mareike Bereswill, Jasmina Kalabic, Kiem Oen, Brian M. Feldman, Brenden Dufault, Jennifer L. Lee, Karen Watanabe Duffy, Ciaran Duffy, N. Ruperto, Nikolay Tzaribachev, Gabriel Vega‐Cornejo, Ingrid Louw, Alberto Berman, I. Calvo, R Cuttica, R. Cimaz, Elisabeth Solau‐Gervais, Rik Joos, Graciela Espada, X Li, Marleen Nys, Robert Wong, Subhashis Banerjee, Alberto Martini, Hermine I. Brunner, Rebecca Nicolai, Margherita Verardo, Adele D’Amico, Luisa Bracci‐Laudiero, Anne‐Laure Mathieu, Sulliman O. Omarjee, Tracy A. Briggs, James O’Sullivan, Simon J. Williams, Eve Smith, Michael W. Beresford, Yanick J. Crow, Madeleine Rooney, Nick Bishop, Joyce Davidson, Jacqui Clinch, Satyapal Rangaraj, Helen Foster, Janet Gardner Medwin, Sue Wyatt, Valentina Litta Modignani, Francesco Baldo, Stefano Lanni, Alessandro Consolaro, Giovanni Filocamo, Helen J. Lachmann, Gian Marco Moneta, Camilla Celani, Bilade Cherqaoui, Linda Rossi-Semerano, Claire Grimwood, Linda Rossi‐Semerano, I. Koné Paut, Denise Lasigliè, Denise Ferrera, Giulia Amico, Marco Di Duca, Roberta Caorsi, Laura Obici, Roberto Ravazzolo, Ryuta Nishikomori, Juan I. Aróstegui, Andrea Petretto, Chiara Lavarello, Elvira Inglese, Federica Vanoni, Michaël Hofer, H. M. Hoffman, Tom van der Poll, U.A. Walker, Tilson Hh, Pascal N. Tyrrell, Isabelle Kone-Paut, Norbert Blank, Hal M. Hoffman, Elisabeth Weißbarth‐Riedel, Boris Huegle, Tilmann Kallinich, Ahmet Gül, Marlen Oswald, Fatma Dedeoğlu, Aki Hanaya, Takako Miyamae, Manabu Kawamoto, Yumi Tani, Takuma Hara, Yasushi Kawaguchi, Satoru Nagata, Hisashi Yamanaka, Almira Ćosićkić, Fahrija Skokić, Belkisa Čolić, Sanimir Suljendić, Anna Kozlova, Irina Mersiyanova, М. В. Панина, Lily Hachtryan, В. И. Бурлаков, Е. В. Райкина, Alexey Maschan, Anna Shcherbina, Banu Çelikel Acar, Meryem Albayrak, Amra Adroviç, Neşe İnan, Serhan Sevgi, Caroline Marie Andreasen, Anne Grethe Jurik, Mia Glerup, Christian Høst, Birgitte Mahler, Ellen‐Margrethe Hauge, Cecilia Lazea, Laura Damian, Rodica Manasia, Chloe Stephenson, Vimal H. Prajapati, Paivi Miettunen, Dilek Yılmaz, Yavuz Tokgöz, Yasin Bulut, Harun Çakmak, Ferah Sönmez, Elif Çomak, Gülşah Kaya Aksoy, Mustafa Koyun, Sema Akman, Yunus Arıkan, Ender Terzıoğlu, Osman Nidai Özdeş, İbrahim Keser, Hüseyin Koçak, Ayşen Bingöl, Aygen Yılmaz, Reha Artan, I. Kone-Paut, A. Simon, Xiaoying Xu, Fatemeh F. Mehregan, Vahid Ziaee, Mohammad Hasan Moradinejad, Giovanna Ferrara, Francesco La Torre, Clotilde Alizzi, Pio D’Adamo, Andrea Taddio, Andrew Zeft, G. Junge, J Gregson, Hulya Zengin, Cagla Kaymakamgil, Dilek Konukbay, Iris Stoler, Judith Freytag, Banu Orak, Christine Seib, Lars Esmann, Eva Seipelt, Faekah Gohar, İsmail Dursun, Sebahat Tülpar, Sibel Yel, Demet Kartal, Murat Borlu, Funda Baştuğ, Hakan Poyrazoğlu, Kader Köse, Mehmet Eren Yüksel, Abdullah Çalışkan, Ahmet B. Cekgeloglu, Kateřina Bouchalová, Jana Fráňová, Marcel Schüller, Marie Macků, Katerina Theodoropoulou, Raffaella Carlomagno, Annette von Scheven-Gête, Claudia Poloni, Dan Cosma, Amanda Rădulescu, Dan Vasilescu, Liliana Rogojan, Simona Rednic, Mihaela Lupșe, Lien De Somer, Pierre Moens, Carine Wouters, Rocío Galindo Zavala, Laura Martín Pedraz, Antonio Luis Urda Cardona, Ilaria Dal Forno, Sara Pieropan, Ombretta Viapiana, Davide Gatti, G. Dallagiacoma, Paola Caramaschi, Domenico Biasi, Daniel Windschall, Ralf Trauzeddel, Hartwig Lehmann, Rainer Berendes, Maria Haller, Manuela Krumrey-Langkammerer, Antje Nimtz-Talaska, Philipp Schoof, Ralf Felix Trauzeddel, Christine Nirschl, Carla Aguilar Blancafort, Sara Marsal Barril, Francisca Aguiar, Duarte Alves, Ana Patrícia Freitas Vieira, Alberto Vieira, Jorge Amil Dias, Iva Brito, Gordana Sušić, Vera Milić, Goran Radunović, Ivan Boričić, Pauline Marteau, C. Adamsbaum, Michel De Bandt, Irène Lemelle, Chantal Job Deslandre, Tú-Anh Tran, Anne Lohse, Pascal Pillet, J. Wipff, C. Gaujoux-Viala, Valérie Devauchelle‐Pensec, Sandra Gran, Olesja Fehler, Stefanie Zenker, Michael Schäfers, Thomas J. Vogl, Severine Guillaume Czitrom, Dirk Foell, Dirk Holzinger, EH Pieter van Dijkhuizen, Francesca Magnaguagno, Laura Tanturri de Horatio, Annemieke S. Littooij, Vitor A. Teixeira, Raquel Campanilho‐Marques, Ana Filipa Mourão, Filipa Ramos, Manuela Costa, Wafa Madan, Orla Killeen, Adriana Rodriguez Vidal, Diana Sueiro Delgado, María Isabel González, Berta López Montesinos, Н. А. Поздеева, Mikhail A Konev, Vladimir Kenis, Г. А. Новик, Ayşenur Paç Kısaarslan, Butsabong Lerkvaleekul, Suphaneewan Jaovisidha, Witaya Sungkarat, Niyata Chitrapazt, Praman Fuangfa, Thumanoon Ruangchaijatuporn, Soamarat Vilaiyuk, Dan Østergaard Pradsgaard, Arne Hørlyck, Anne Helene Spannow, Carsten Heuck, Talia Diaz, Fernando López García, Lorenia De La Cruz, Nadina Rubio, Joanna Świdrowska-Jaros, Elżbieta Smolewska, Mirta Lamot, Lovro Lamot, Mandica Vidović, Edi Paleka Bosak, Ivana Radoš, Miroslav Harjaček, Polymnia Louka, R. Hagoug, Chiara Trentin, Olga Kubassova, M. Hinton, Mikael Boesen, О.А. Oshlіanska, Illya Chaikovsky, Georg Mjasnikov, Anatoly Kazmirchyk, Irene Borzani, P. Cressoni, E. Dzsida, Fabrizia Corona, Alenka Gagro, Agneza Marija Pasini, Goran Roić, Ozren Vrdoljak, Lucija Lujić, Matija Žutelija-Fattorini, Monika Esser, Deepthi Raju Abraham, Craig Kinnear, Glenda Durrheim, Eileen G. Hoal, Victoria B. Nikolayenko, Kubilay Şahin, Yaşar Karaaslan, Adele Civino, Giovanni Alighieri, Sergio Davì, Roberto Rondelli, Andrea Magnolato, Francesca Ricci, Alma Nunzia Olivieri, V. Gerloni, Bianca Lattanzi, Francesca Soscia, Alessandro De Fanti, Stefania Citiso, Lorenzo Quartulli, Maria Cristina Maggio, Manuela Marsili, Maria Antonietta Pelagatti, Valentino Conter, Franca Fagioli, Andrea Pession, Marco Garrone, Mariangela Rinaldi, Stella Maris Garay, Berit Flatø, Angela Aquilani, Simona Cascioli, Ivan Caiello, Rita Carsetti, Fabrizio De Benedetti, Emily Robinson, Salvatore Albani, Wilco de Jager, Sytze de Roock, Trang T. Duong, Justine A. Ellis, Laetitia Jervis, Lucy Marshall, Elizabeth Mellins, Kirsten Minden, Jane Munro, Peter A. Nigrovic, Jason Palman, Sunil Sampath, Laura E. Schanberg, Susan D. Thompson, Wendy Thomson, Richard Veselý, Chris Wallace, Christopher Williams, Qiong Wu, M. B. Seyger, Dilek Arikan, J K Anderson, Andrew Lazar, D. A. Williams, C. Wang, R. Tarzynski-Potempa, J. S. Hymans, Erika Scoccimarro, Irene Pontikaki, Teresa Giani, Alessandro Ventura, Pier Luigi Meroni, Gaetana Minnone, Marzia Soligo, Luigi Manni, Noortje Groot, Ingrid Herta Rotstein Grein, R Schepp, Guy A. M. Berbers, C. C. Barbosa Sandoval de Souza, Virgínia Paes Leme Ferriani, Giampaolo Pileggi, Sytze de Roock, Silvia Scala, Elisa Patrone, Casper Schoemaker, Wendy Costello, Suzanne Parsons, Jean-David Cohen, Damien Bentayou, Marc-Antoine Bernard Brunel, Sonia Tropé, Jens Klotsche, Miriam Listing, Martina Niewerth, Gerd Horneff, A. Thon, Hans‐Iko Huppertz, Kirsten Mönkemöller, Achille Marino, Stefano Stagi, Niccolò Carli, Federico Bertini, Adriana S. Díaz-Maldonado, Sally Pino, Pilar Guarnizo, Alfonso Ragnar Torres Jiménez, Berenice Sánchez‐Jara, Eunice Solís-Vallejo, Adriana Ivonne Céspedes-Cruz, Maritza Zeferino-Cruz, Julia Veronica Ramirez-Miramontes, Deepti Suri, Amit Rawat, Nandita Kakkar, Balahan Makay, Özge Altuğ Gücenmez, Erbil Ünsal, Karina Mördrup, Anna Vermé, Christina Peterson, Caroline Freychet, Jean Louis Stéphan, Cathryn E. Harkness, Leanne Foster, Emma Henry, Pauline Taggart, Coşkun Fırat Özkeçeci, Esra Kurt, Gökalp Başbozkurt, Daiva Gorczyca, Jacek Postępski, Aleksandra Czajkowska, Bogumiła Szponar, Mariola Paściak, Anna Gruenpeter, Iwona Lachór-Motyka, Daria Augustyniak, Edyta Olesińska, Emediong Santhus Asuka, Tatyana Golovko, Samuel U. Aliejim, Emilio Inarejos Clemente, E Jimenez, Joan Calzada Hernández, Sergi Borlan Fernández, Clara Roca, David Moreno Romo, N. Rodríguez Nieva, Juan Manuel Mosquera Angarita, Esmeralda Núñez Cuadros, Antonio Urda-Cardona, Antonio Fernández‐Nebro, Marina García-Prat, Mónica Martínez‐Gallo, Ricardo Pujol‐Borrell, Ana M. Marín Sánchez, Consuelo Modesto Caballero, Étienne Merlin, Sylvie Fraïtag, Jean‐Louis Stephan, Christine Bodemer, F Annoni, Giancarla Di Landro, Sofia Torreggiani, Marta Torcoletti, Antonella Petaccia, Georgina Tiller, Jo Buckle, A. Cox, Peter Gowdie, Roger C. Allen, Jonathan Akikusa, Hayde Guadalupe Hernández-Huirache, Edel Rafael Rodea-Montero, William A. Fahy, Christelle Sordet, Karin B. Berggren, Johanna T. Kembe, Joyce Bos, Wineke Armbrust, Marco van Brussel, Jeanette Cappon, Pieternel Dijkstra, Jan H. Geertzen, Marion van Rossum, Pieter J.J. Sauer, Otto Lelieveld, Levent Buluç, Gür Akansel, Bahar Müezzínoğlu, Zelal Ekinci, Л. В. Рычкова, T. A. Knyazeva, Анна Погодина, Tatyana Belova, Tamara Mandzyak, Ekaterina Kulesh, Alessandro Cafarotti, Cosimo Giannini, Roberta Salvatore, Giuseppe Lapergola, Caterina Di Battista, M. Loredana Marcovecchio, Raffaella Basilico, Piernicola Pelliccia, Francesco Chiarelli, Luciana Breda, Beverley Almeida, Sarah Tansley, Harsha Gunawardena, Neil McHugh, Jessie Aouizerate, Marie De Antonio, Christine Barnérias, Guillaume Bassez, Isabelle Desguerre, Romain K. Gherardi, Jean‐Luc Charuel, François‐Jérôme Authier, Cyril Gitiaux, Charles H. Spencer, C. Yung Yu, Brent H. Adler, Sharon Bout‐Tabaku, Katherine E. Lintner, Melissa Moore‐Clingenpeel, Liza McCann, Nicola Ambrose, Mario Cortina‐Borja, Lucy R. Wedderburn, Claas Hinze, Prasad T. Oommen, Fabian Speth, Claudio Lavarello, Lisa G. Rider, Rohit Aggarwal, Sheila Oliveira, Rubén Cuttica, Michel Fischbach, Gary Sterba, Karine Brochard, Frank Dressler, Patrizia Barone, Rubén Burgos‐Vargas, Elizabeth Chalom, Marine Desjonquères, Anders Fasth, Rose-Marie Herbigneaux, Claire Hoyoux, Frederick W. Miller, Jiří Vencovský, Erdal Sağ, Gülsev Kale, Haluk Topaloglu, Beril Talim, Francesco Zulian, Tadej Avčin, Roberto Marini, Anne Pagnier, M. Rodière, Christine Soler, R. ten Cate, Jelena Vojinović, Ana V. Villarreal, Nydia Acevedo, Yuridiana Ramírez, Enrique Faugier, Rocío Maldonado, Bita Arabshahi, John H. Lee, Ian Leibowitz, Lawrence Okong’o, Jo M. Wilmshurst, Christiaan Scott, Ezgi Deniz Batu, Nagehan Emiroglu, Hafize Emine Sonmez, Gökçen Dilşa Tuğcu, Zehra Serap Arici, Ebru Yalçın, Deni̇z Doğru, Uğur Özçelik, Mithat Haliloğlu, Nural Ki̇per, Masato Yashiro, Mutsuko Yamada, Toshihiko Yabuuchi, Tomonobu Kikkawa, Nobuyuki Nosaka, Yosuke Fujii, Yukie Saito, Hirokazu Tsukahara, Nora AlMutiari, Mohammed Muzaffer, Rawiah shehata, Adel Alwahadneh, Reem Abdwani, Safia Al-Abrawi, Mohammed Abu-shukair, Zeyad El-Habahbeh, Abdullah Alsonbul, Aleksandra Szabat, Monika Chęć, Violetta Opoka‐Winiarska, Anju Gupta, Biman Saikia, Ranjana W. Minz, Christine Arango, Clara Malagón, María del Pilar Gómez, Ricardo Yépez, Tatiana González, Camilo Vargas, Marta Balzarin, Biagio Castaldi, Elena Reffo, Francesca Sperotto, Giorgia Martini, Alessandra Meneghel, Ornella Milanesi, Maria Teresa Terreri, Rolando Cimaz, Vanessa Smith, T. Avčin, Maria Jose Santos, Dana Němcová, Cristina Battagliotti, Kathryn S. Torok, Eileen Baildem, Michael Blakley, Kim Fligelstone, Antonia Kienast, Clare Pain, Amanda Saracino, Gabriele Simoni, Lisa Weibel, Mikhail M. Kostik, Nicola Helmus, Maria K. Osminina, N. Geppe, Olga V. Niconorova, Olesya V. Karashtina, Oksana V. Abbyasova, О.В. Шпитонкова, Sinem Durmuş, Hafize Uzun, Thomas Lehman, Flávio Sztajnbok, Maria Carolina dos Santos, Liora Harel, Mahesh Janarthanan, Angela Mauro, Eleonora Fanti, Fabio Voller, Franca Rusconi, Fernando García Rodríguez, Ana Victoria Villarreal-Treviño, Angel J. Flores-Pineda, Paola B. Lara-Herrea, Diego R. Salinas-Encinas, Talia Diaz-Prieto, Maria R. Maldonado-Velazquez, Sarbelio Moreno‐Espinosa, Enrique Faugier Fuentes, Mirella Crapanzano, Ilaria Parissenti, Surjit Singh, Pandiarajan Vignesh, Kavitha Gopalan, Savita Verma Attri, Alan D. Salama, David Jayne, Mark Little, Yulia Kostina, Galina Lyskina, Alena Torbyak, Olga Shirinsky, Maria Francesca Gicchino, Maria Cristina Smaldone, Mario Diplomatico, Alma Nunzia Olivieri, Cole Spencer, Richard E. McClead, Hiren Patel, Chung-Yung Yu, Dita Cebecauerová, Edita Kabíčková, Martin Kynčl, Daniela Chroustová, J Hoza, Vladimı́r Tesař, Tuncay Hazırolan, Fatih Özaltın, Fernanda Fachetti Xavier de Almeida, Isabela H. Faria de Paula, Maíra M. Sampaio, F. Arita, Andressa G. Alves, Eunice M. Okuda, Fernanda Falcini, Francesca Marini, Gemma Lepri, Marco Matucci‐Cerinic, Maria Luisa Brandi, Hakan Kısaoğlu, Sema Mısır, Selim Demir, Yüksel Aliyazıcıoğlu, Mukaddes Kalyoncu, Carlos Eduardo Benetti Ramalho, Joan Calzada‐Hernández, Rosa Bou, E. Iglesias, Judith Sánchez-Manubens, Fredy Hermógenes Prada Martínez, Marek Böhm, Kamran Mahmood, Valentina Leone, Mark Wood, Kenichi Yamaguchi, Satoshi Fujikawa, Kyu Yeun Kim, Do Young Kim, Dong Soo Kim, Maka Ioseliani, Ivane Chkhaidze, Nana Tskhakaia, Shorena Tvalabeishvili, Aleksandre Kajrishvili, Maiko Takakura, Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Akihiro Yachie, Giovanni Corsello, Maryam Piram, Carla Maldini, Sandra Biscardi, Nathalie Desuremain, Catherine Orzechowski, Emilie Georget, D. Regnard, Alfred Mahr, Mihaela Spârchez, Zeno Spârchez, Nydia Acevedo Silva, Yuridiana Ramirez Loyola, Talia Diaz Prieto, María del Rocío Maldonado Velázquez, Pilar Ortiz Pérez, Sagar Bhattad, Jitendra Shandilya, Ana Villarreal, Olga Shpitonkova, Zeynep Birsin Özçakar, Suat Fítöz, Fatoş Yalçınkaya, AnnaCarin Horne, Francesca Minoia, Francesca Bovis, Priyankar Pal, Kimo Stein, Sandra Enciso, Michael Jeng, Despoina Maritsi, Randy C. Cron, Anne Thorwarth, Anne Sae Lim von Stuckrad, Angela Rösen‐Wolff, Hella Luksch, Patrick Hundsdoerfer, Peter Krawitz, Sezgin Şahin, Şebnem Sara Kılıc, Zehra Serap Arıcı, Fatih Mehmet Keleşoğlu, Ruhan Düşünsel, María Miranda-Garcia, Carolin Pretzer, Michael Frosch, Angela McArdle, Niamh Callan, Belinda Hernández, Miha Lavric, Oliver FitzGerald, Stephen R. Pennington, Joachim Peitz, Joern Kekow, A. Klein, Anna Carina Schulz, Frank Weller‐Heinemann, Anton Hospach, J. A. M. de Haas, Karen Put, Jessica Vandenhaute, Anneleen Avau, Annemarie van Nieuwenhuijze, Ellen Brisse, Tim Dierckx, Omer Rutgeerts, Josselyn E. Garcia‐Perez, Jaan Toelen, Mark Waer, Georges Leclercq, An Goris, Johan Van Weyenbergh, Adrian Liston, Patrick Matthys, Yasuo Nakagishi, Michael J. Ombrello, Victoria Arthur, Anne Hinks, Patricia Woo, B. Stanimirovic, Biljana Djurdjevic-Banjac, Olivera Ljuboja, Boris Hügle, Margarita Onoufriou, Kenza Bouayed, Sanae El Hani, N. Mikou, Nunu Shelia, Mari Laan, Jaanika Ilisson, Chris Pruunsild
Bibliographic record
VenuePediatric Rheumatology · 2017
Typearticle
Languageen
FieldMedicine
TopicAutoimmune and Inflammatory Disorders Research
Canadian institutionsUniversity of ManitobaSunnybrook HospitalUniversity of TorontoWestern UniversityInstitute for Clinical Evaluative SciencesUniversity of OttawaSimon Fraser UniversityUniversity of CalgaryMount Sinai HospitalStollery Children's HospitalAlberta Children's HospitalUniversity of British ColumbiaHospital for Sick ChildrenUniversity of AlbertaSickKids FoundationBC Children's Hospital
FundersNIH Clinical CenterMedizinische Fakultät, Heinrich-Heine-Universität DüsseldorfNovartis PharmaHacettepe ÜniversitesiMinistry of Health, Labour and WelfareCleveland ClinicUniversity College LondonUniversity of TorontoAdnan Menderes ÜniversitesiGreat Ormond Street Hospital for ChildrenHebrew University of JerusalemMurdoch Children's Research InstituteDuke-NUS Medical SchoolChildren’s Hospital of Wisconsin Research InstituteHospital for Sick ChildrenPfizer
KeywordsMedicineSTAT1IRF3StingPeripheral blood mononuclear cellStimulator of interferon genesPhosphorylationInterferonRheumatologyImmunologyInternal medicineCancer researchReceptorBiologyInnate immune systemCell biologyIn vitro
Abstract
Introduction: Gain-of-function mutations in TMEM173 encoding STING (Stimulator of Interferon Genes) underlie a novel type I interferonopathy, minimally responsive to conventional immunosuppressive therapies and associated with high childhood morbidity and mortality. A newly emerging treatment strategy in STING-related inflammation aims to control interferon (IFN) signalling post-binding of the IFN receptor, by targeting JAK1/2. We hypothesized that inhibition of IFN production itself might represent an alternative therapeutic approach in this disease. Objectives: To evaluate the effect of BX795, a TBK1 inhibitor, on constitutive production of type I IFN in TMEM173-associated vasculopathy. Methods: Human embryonic kidney 293 cells (HEKs) transfected with wild-type (WT) or mutant STING, and peripheral blood mononuclear cells (PBMCs) from three patients were treated with BX795 2 M. The effect of BX795 on TBK1 signalling cascade was assessed in HEKs by western blotting and IFN reporter assay. In patient cells, IFN production was assessed by ultra-sensitive digital ELISA, STAT1 phosphorylation status by flow cytometry and RNA expression of IFNstimulated genes (ISG) by qPCR.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.028
Threshold uncertainty score0.856
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.024
GPT teacher head0.272
Teacher spread0.248 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations20
Published2017
Admission routes2
Has abstractyes