“Onion peel” glycodendrimer syntheses using mixed triazine and cyclotriphosphazene scaffolds
Bibliographic record
Abstract
An expeditious synthetic protocol for the construction of glycodendrimers is illustrated using the newly discovered “onion peel” strategy. The onion peel approach and orthogonal coupling strategies were accomplished with rationally design sequential modifications of cyanuric acid. Carefully chosen building blocks and their effective attachment by chemoselective atom economical click reactions, namely Cu (I) azide–alkyne cycloaddition reaction (CuAAC) and photocatalyzed thiol-ene reaction (TEC), allowed rapid build-up of glycodendrimers in contrast to traditional dendrimers syntheses that are based on the repetitive use of identical building blocks to form each layer. The newly formed glycodendrimers were evaluated for their capacity to cross-link carbohydrate-lectin interactions using dynamic light scattering (DLS). Rapid increase in particle size was observed as a function of time when compared to their monomer counterparts resulting from the multivalent lectin cross-linking ability of the new glycodendrimers.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".