The Behavioural Characterization of Dopamine D2 Receptor-related Protein-protein Interactions
Bibliographic record
Abstract
Dopamine is one of the prominent catecholamine neurotransmitters in mammalian central nervous system. Dopamine is critically involved in a wide range of physiological functions including movement, motivation, reward, learning and memory, etc. The dopaminergic system exerts or modulates these physiological actions through four major signaling pathways. Clinically, the dysfunctions of the dopaminergic system are implicated in the patho-physiology of disorders such as Parkinson’s disease (PD), schizophrenia, attention deficit/hyperactivity disorder (ADHD), etc. At the molecular level, dopamine exerts its actions via its binding to dopaminergic receptors such as dopamine D2 receptors (D2R). In this study, two D2R-related protein-protein interactions were examined in vivo regarding their behavioural effects. The disruption of D2R-DAT interaction was found to elevate voluntary movement in normal animals as well as in animals modeling acute dopamine depletion. On the other hand, the interference in the D2R-DISC1 protein complex exhibited anti-psychotic actions in two animal models of schizophrenia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".