Bibliographic record
Abstract
Oral phosphodiesterase type 5 (PDE5) inhibitor therapy is recommended in guidelines as first-line therapy for erectile dysfunction because of its convenience, high efficacy and low rates of side effects.Tadalafil (Cialis, Lilly ICOS, USA), recently approved in Canada and the United States as an oral therapy for erectile dysfunction, has a half-life of 17.5 h, which offers men a longer period of effectiveness than other PDE5 inhibitors.Five randomized, double-blind, placebocontrolled, multicentre trials (four with patients in Canada) studied tadalafil at fixed doses of 2.5, 5, 10, or 20 mg.In an integrated analysis, tadalafil gave statistically significant improvements in all efficacy outcomes compared with placebo.A global assessment question found 81% of men taking tadalafil 20 mg reported overall improvement in their erections.In a separate study, tadalafil significantly improved erectile function 36 h after dosing.Tadalafil has been generally well-tolerated, with side effects comparable to those seen with other PDE5 inhibitors.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".