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Record W2624387478 · doi:10.1016/s2213-2600(17)30215-1

Efficacy and safety of lumacaftor and ivacaftor in patients aged 6–11 years with cystic fibrosis homozygous for F508del-CFTR : a randomised, placebo-controlled phase 3 trial

2017· article· en· W2624387478 on OpenAlexaff
Félix Ratjen, Christopher Hug, Gautham Marigowda, Simon Tian, Xiaohong Huang, Sanja Stanojevic, Carlos Milla, Paul D. Robinson, David Waltz, Jane C. Davies, Margaret Rosenfeld, Timothy D. Starner, George Retsch‐Bogart, James F. Chmiel, David M. Orenstein, Ronald C. Rubenstein, Seth Walker, Alexandra G. Cornell, Fadi Asfour, Philip Black, John L. Colombo, Deborah Froh, Susanna A. McColley, F. Ruiz, Diana Quintero, Alicia Casey, Gary A. Mueller, Patrick A. Flume, F. R. Livingston, Michael J. Rock, Brian O’Sullivan, H. Joel Schmidt, Thomas Lahiri, John McNamara, Aaron Chidekel, Laura A. Sass, Thomas G. Keens, David J. Schaeffer, Melinda Solomon, Mark Chilvers, Larry C. Lands, Sibylle Junge, Matthias Griese, Doris Staab, Tacjana Pressler, Silke van Koningsburggen-Rietschel, Lutz Naehrlich, Alastair Reid, Ian M. Balfour‐Lynn, Don S. Urquhart, Timothy Lee, À. Munck, Isabelle Sermet‐Gaudelus, Philippe Reix, Anne Malfroot, S. Bui, Hiranjan Selvadurai, Philip Robinson, Claire Wainwright, Barry Clements, Jodi Hilton, Lena Hjelte

Bibliographic record

VenueThe Lancet Respiratory Medicine · 2017
Typearticle
Languageen
FieldMedicine
TopicCystic Fibrosis Research Advances
Canadian institutionsSickKids FoundationHospital for Sick ChildrenUniversity of Toronto
FundersNational Institutes of HealthCystic Fibrosis ResearchVertex Pharmaceuticals
KeywordsIvacaftorMedicineCystic fibrosisCystic fibrosis transmembrane conductance regulatorPlaceboInternal medicineGastroenterologyPathology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.021

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0040.004
Bibliometrics0.0000.000
Science and technology studies0.0010.002
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0040.004
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.348
Teacher spread0.314 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations295
Published2017
Admission routes1
Has abstractno

Explore more

Same venueThe Lancet Respiratory MedicineSame topicCystic Fibrosis Research AdvancesFrench-language works237,207