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Record W2624801309 · doi:10.1016/j.jacl.2017.06.005

A case of hypocholesterolemia and steatosis in a carrier of a PCSK9 loss-of-function mutation and polymorphisms predisposing to nonalcoholic fatty liver disease

2017· article· en· W2624801309 on OpenAlexaff
Mathilde Di Filippo, B. Vokaer, Nabil G. Seidah

Bibliographic record

VenueJournal of clinical lipidology · 2017
Typearticle
Languageen
FieldMedicine
TopicLipoproteins and Cardiovascular Health
Canadian institutionsUniversité de MontréalMontreal Clinical Research Institute
Fundersnot available
KeywordsMedicineSteatosisHypocholesterolemiaNonalcoholic fatty liver diseaseFatty liverInternal medicineLoss functionDiseaseMutationGastroenterologyGeneticsGeneCholesterolPhenotypeBiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

The three-model screen

all 5,600 screened works →

All three models called this out of scope.

stratum: aff_core · design weight: 5595.24 (the sample is stratified; any rate computed without the weight is wrong)
Claude Opus 4.8OUT
genre: empirical
about Canada: no
confidence: high

Clinical case report of a PCSK9 mutation carrier.

GPT-5.6 (high)OUT
genre: empirical
about Canada: no
confidence: high

This reports a clinical case involving a genetic mutation and liver disease, not research itself.

Grok 4.5OUT
genre: empirical
about Canada: no
confidence: medium

Clinical genetics case of PCSK9 mutation and steatosis; title-domain clear despite empty abstract.

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.006
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: Case report
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score0.000

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.006
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0020.003
Bibliometrics0.0050.002
Science and technology studies0.0040.003
Scholarly communication0.0020.002
Open science0.0030.003
Research integrity0.0100.004
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.066
GPT teacher head0.380
Teacher spread0.313 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designCase report
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations11
Published2017
Admission routes1
Has abstractno

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