Genetic loci associated with heart rate variability and their effects on cardiac disease risk
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- Meta-epidemiology (narrow), Research integrity
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: Other designConsensus signal: none
- Genre
- Candidate signal: ReviewConsensus signal: Review
- Teacher disagreement score
- 0.987
- Threshold uncertainty score
- 1.000
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.304 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Abstract Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755 ), expression quantitative trait loci (eQTLs) (influencing GNG11 , RGS6 and NEO1 ), or are located in genes preferentially expressed in the sinoatrial node ( GNG11 , RGS6 and HCN4) . Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (−0.74< r g <−0.55) and blood pressure (−0.35< r g <−0.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants ( GNG11 , RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Nature Communications
- Topic
- Heart Rate Variability and Autonomic Control
- Field
- Medicine
- Canadian institutions
- Université de MontréalUniversity of TorontoUniversity Health NetworkMount Sinai HospitalMontreal Heart Institute
- Funders
- National Center for Advancing Translational SciencesNational Institute of Dental and Craniofacial ResearchNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteGillings School of Public HealthNational Institute of Diabetes and Digestive and Kidney DiseasesKnut och Alice Wallenbergs StiftelseTurun Yliopistollinen KeskussairaalaTaysPaavo Nurmen SäätiöScience for Life LaboratoryUppsala Multidisciplinary Center for Advanced Computational ScienceUniversity of MiamiWetenschappelijk Onderzoek- en DocumentatiecentrumMarcus och Amalia Wallenbergs minnesfondHögskolan DalarnaSydäntutkimussäätiöUppsala UniversitetMedical Research CouncilNational Institute of General Medical SciencesLeids Universitair Medisch CentrumU.S. Department of Veterans AffairsEmil Aaltosen SäätiöVetenskapsrådetSultan Qaboos UniversityJuho Vainion SäätiöNational Center on Minority Health and Health DisparitiesHjärt-LungfondenDeutsche ForschungsgemeinschaftNederlandse Organisatie voor Wetenschappelijk OnderzoekOffice of Dietary SupplementsAcademy of FinlandUniversiteit LeidenRijksuniversiteit GroningenTampereen TuberkuloosisäätiöKelaEuropean Science FoundationNational Institute on Minority Health and Health DisparitiesErasmus Universitair Medisch Centrum RotterdamLandstinget DalarnasEuropean CommissionBritish Heart FoundationWellcome TrustErasmus Medisch CentrumVrije Universiteit AmsterdamUniversity of WashingtonYale UniversityFoundation for Cardiovascular ResearchNorthwestern UniversityNational Institutes of HealthSan Diego State UniversitySuomen KulttuurirahastoZonMwWomen's Health InitiativeYrjö Jahnssonin SäätiöNetherlands Heart InstituteUniversitair Medisch Centrum GroningenEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentU.S. Department of Health and Human Services
- Keywords
- Single-nucleotide polymorphismHeart rate variabilityGenome-wide association studyQuantitative trait locusBiologyGeneticsGenetic variationGenetic associationExpression quantitative trait lociGeneHeart rateGenotypeBlood pressureEndocrinology
- Has abstract in OpenAlex
- yes