Bibliographic record
Abstract
The relationship between gonadal hormones and hippocampal neuroplasticity remains controversial. This thesis explores the effects of estradiol on dendritic spine density (DSD) in CA1 and CA3 of the hippocampus in intact female rats. Results showed a mixed-mode response to higher estradiol: CA1 DSD significantly increased in the apical dendritic tree, but not in CA3. Despite evidence that CA3 synaptic characteristics are dependent on BDNF and estradiol interactions, other mechanisms maybe involved. This thesis also addresses the connection between androgen and BDNF-dependent mechanisms on hippocampal neuroplasticity in male mice. Gonadectomy led to atrophy of CA3 neurons but did not alter BDNF transcript or protein expression. Interestingly, surgerized groups expressed greater proBDNF 8-12 days, not 27-30 days following surgery, and atrophy in CA3 neurons compared to un-surgerized groups. It is likely that surgical stress might have played a role in the neuromorphological changes observed. This is key to understanding hippocampal- dependent cognitive dysfunction.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".