1P1-V05 Application to the Drug-Screening System Using Microfluidic Gradient Generator(Nano/Micro Fluid System)
Why this work is in the frame
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Bibliographic record
Abstract
This paper presents a high-throughput methodology to analyze the function of an ATP binding cassette transporter (ABC transporter) by using a microfluidic device that generates a concentration gradient of substrates. In drug development process, determination of the concentration at which the transport of a drug is inhibited by the other one by 50% (IC_<50>) is an important value for safe and effective use of drugs. To determine IC_<50>, substrate transport by ABC transporters at different concentrations must be evaluated. We applied a microfluidic gradient generator, which makes various concentrations of substrates in a single device, for rapid IC_<50> determination. After incubation of ABC transporters at 5 different substrate concentrations in a gradient generator, we succeeded in detecting the difference of substrate transport revealed by the different fluorescence intensity from ABC transporter vesicles.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it