Bibliographic record
Abstract
The epidemic of Zika Virus (ZV) drastically affected the health of more than one million people in Brazil resulting in twenty-fold increase of microcephaly (head circumference of newborn baby being less than or equal to thirty-two cms) in infected pregnant women.ZV crosses the placental barrier between maternal and fetal compartments.ZV has been found in amniotic fluid and fetal brain tissue of the human pregnancies complicated with ZV infection and microcephaly supporting cause and effect relationship between ZV and microcephaly.New knowledge about how ZV enters into the cells is mandatory for preventive and therapeutic research.ZV is a Flavivirus, therefore the Flavivirus receptors are candidate receptors for ZV too.ZV has been associated with high level of TYRO3 and AXL component of TAM, a Tyrosine Kinase receptor family, expression in the infected skin cells and neuronal stem cells.It predicts that AXL receptors may facilitate ZV entry into the trophoblasts and endothelial cells lining the fetal vessels present in the placenta.This hypothesis stems from the reported studies on ZV and AXL receptor expression, both in human tissues and animal models.If our hypothesis proves to be valid, it would be a great step towards the drug and therapeutic development to prevent ZV crossing the placental barrier and resulting in complications.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".