Brain geometry persistent homology marker for Parkinson's disease
Why this work is in the frame
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Bibliographic record
Abstract
The geometry of the human brain changes due to age and neurodegeneration. The brain geometry is expected to undergo a similar change in shape with a normal aging, however such change may differ in patients suffering from neurodegenerative disorders. In the novel framework proposed in this work, we model the brain geometry as a 3D point cloud and study the algebraic topology features of this point cloud. Specifically, we compute the persistence timelines of a simplicial complex in a multiscale simplicial homology of the underlying topology space. Further, persistence landscape summary features are obtained from the timelines and studied for their difference between the two groups. The statistical significance obtained in a permutation testing experiments highlights the ability of the persistence landscape features to differentiate between the PD and healthy control brain geometry.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it