Abstract P007: Hypertension and Myocardial Mechanics in Patients with Hypertrophic Cardiomyopathy
Bibliographic record
Abstract
Introduction: Strain abnormalities in patients with Hypertrophic Cardiomyopathy (HCM) is associated with poor prognosis. Our aim was to assess whether the presence of hypertension in HCM altered myocardial mechanics using strain echocardiographic imaging. Hypothesis: Hypertension is a risk factor for diminished deformation in patients with HCM. Methods: A retrospective chart review of patients undergoing HCM evaluation at our facility between December 2008 and December 2011 was performed. Patients were divided into subsets based on the presence of hypertension as a documented diagnosis. All patients had comprehensive echocardiographic assessments with strain imaging. Clinical data was extracted from the electronic medical record. Comparisons in strain values were made between both subsets. Results: A total of 200 patients was assessed. The average age was 56 years (60% male) and 42.5% of the patients had a diagnosis of hypertension. Global longitudinal strain, Mid strain, Basal strain, Anterior, Lateral, Inferior, Inferolateral strain had no relation to the presence of hypertension. Septal strain (mean without hypertension -14.306 vs with hypertension -16.071, p value: .0069) Inferoseptal strain (mean without hypertension -12.813 vs with hypertension -15, p value: .0018), and Anteroseptal deformation (mean without hypertension -15.301 vs with hypertension -16.784, p value: .0445) however, was increased in patients with hypertension compared to patients with no history of hypertension (See Table) Conclusions: The presence of hypertension is associated with septal strain abnormalities. Thus, future exploration of hypertension control and hypertrophic cardiomyopathy prognosis and outcomes need to be explored.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".