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Record W2673505836

Cerebral Blood Flow Assessment in Children with Sickle Cell Disease

2012· dissertation· en· W2673505836 on OpenAlexaff
A Behpour

Bibliographic record

VenueTSpace (University of Toronto) · 2012
Typedissertation
Languageen
FieldMedicine
TopicHemoglobinopathies and Related Disorders
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsCerebral blood flowMedicineDiseasePediatricsIntensive care medicineInternal medicine
DOInot available

Abstract

fetched live from OpenAlex

This thesis investigated the role of CBF assessment in the management of stroke in children with\nsickle cell disease (SCD). It is divided into two parts. In the first part, a systematic review of CBF\nassessment using different imaging modalities in SCD children was designed. The prevalence of\nCBF abnormalities was found to be equal to or higher than those of structural MRI and\ntranscranial Doppler (TCD) in SCD children who have not experienced stroke. Studies reviewed\nsuggested CBF assessment in SCD could aid in addressing brain abnormalities at the tissue level.\nIn the second part, the arterial spin labeling (ASL) technique was used to depict CBF\nabnormalities in SCD children. ASL demonstrated perfusion abnormalities that seem to remain\ninvisible in TCD measurements; CBF interhemispheric asymmetries were associated with\nclinically silent infarctions with no corresponding flow velocity interhemispheric asymmetries\nassessed with TCD.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.218
Teacher spread0.214 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2012
Admission routes1
Has abstractyes

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