1A2-O02 The Formation of DNA Logic Gate on Lipid covered droplet Network(Nano/Micro Fluid System)
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Bibliographic record
Abstract
This paper experimentally demonstrates a biological NAND logic gate using DNA and biological nanopores. Biological nanopores can be used for single molecule detection; in our previous works, it was confirmed that ssDNA is driven throughαHL, a biological nanopore, incorporated in bilayer lipid membranes(BLMs) but not double-stranded DNA(dsDNA). In this study, these passing and non-passing phenomena were applied as the binary system and logic gates, and NAND gate was successfully demonstrated. Furthermore, we developed this NAND system into four droplet network. Droplets are covered with lipid and linked through biological nanopores. This droplet network enabled DNA to be input by voltage ON/OFF application. We believe that this system enables direct connection between electrical systems and computing based on biomolecules.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it