Abstract 273: Levels Of Vcam-1 Are Associated With Flow-mediated Dilation In Healthy African American Adults
Bibliographic record
Abstract
Background: Vascular cell adhesion molecule-1 (VCAM-1) mediates the adhesion of monocytes to vascular endothelium, which play a role in the development of endothelial dysfunction and atherosclerosis. Flow-mediation dilation (FMD) is an endothelium-dependent response, which is mediated by nitric oxide and closely related to endothelial function. The purpose of the study was to test whether levels of VCAM-1 were associated the endothelial-dependent (FMD) in normotensive African Americans. Normotensives were studied in order to eliminate the influence of hypertension. Methods and Results: Blood was collected in 22 subjects aged 41-62 yrs with normal blood pressure (125.0 ± 9.1 mmHg) after 12 hr fast. Plasma was obtained by centrifugation within 15 min after collection in 4 degree. A commercially available solid phase sandwich enzyme linked immuno-sorbent assay kit was used to detect VCAM-1 levels in plasma. FMD was measured after 5-min cuff occlusion using Doppler ultrasound. The maximum FMD diameters were calculated. In the entire study population, levels of VCAM-1 (556.92 ± 154.20 ng/mL) were negatively correlated with the true peak FMD (FMD: 7.81 ± 2.22 %, r=-0.484, P=0.023). Conclusion: Levels of VCAM-1 were associated with endothelial responsiveness in healthy African Americans with normal blood pressure. These results suggest that the level of VCAM-1 may be a predictive of endothelial dysfunction in the unique healthy populations.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".