Influenza Induces Platelet-endothelial Adhesion: Implications for Acute Respiratory Distress Syndrome after Influenza Virus Infection
Bibliographic record
Abstract
Loss of barrier integrity of the lung microvascular endothelium is a prerequisite for acute respiratory distress syndrome (ARDS). Severe influenza is complicated by ARDS, and treatment with antiviral therapy is only partially effective at reducing mortality. Recent studies have pinpointed platelets involvement in ARDS pathogenesis. Our lab has recently reported that human influenza can infect lung endothelial cells in vitro, but the functional consequence of such infection is incompletely understood. We therefore studied whether influenza infection of lung endothelium can lead to enhanced platelet adhesion and if so, by what mechanism. We observed an increase in endothelial-platelet interaction after influenza infection of the endothelium in vitro. The increased interaction was due to upregulation of fibronectin that enabled endothelial-platelet adhesion via platelet integrin alpha-5 beta-1. Inhibition of platelets using acetylsalicylic acid (ASA) improved hypoxemia and survival of mice infected with influenza, further implicating platelets in the pathogenesis of severe influenza..
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".