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Record W2733664608 · doi:10.1073/pnas.1706865114

Disruption of a horizontally transferred phytoene desaturase abolishes carotenoid accumulation and diapause in <i>Tetranychus urticae</i>

2017· article· en· W2733664608 on OpenAlexafffund
Astrid Bryon, Andre H. Kurlovs, Wannes Dermauw, Robert Greenhalgh, Maria Riga, Miodrag Grbić, Luc Tirry, Masahiro Osakabe, John Vontas, Richard M. Clark, Thomas Van Leeuwen

Bibliographic record

VenueProceedings of the National Academy of Sciences · 2017
Typearticle
Languageen
FieldMedicine
TopicAntioxidant Activity and Oxidative Stress
Canadian institutionsWestern University
FundersVlaamse regeringOntario Genomics InstituteFonds Wetenschappelijk OnderzoekJapan Society for the Promotion of ScienceMinistry of Education, Culture, Sports, Science and TechnologyOntario GenomicsNational Institutes of HealthNational Science FoundationGovernment of CanadaGenome CanadaNational Institute of General Medical SciencesUniversity of Utah
KeywordsPhytoeneTetranychus urticaeDiapauseCarotenoidPhytoene desaturaseBiologyHorticultureBotanyPEST analysisLarvaLycopeneBiochemistryBiosynthesisGene

Abstract

fetched live from OpenAlex

Significance In animals, carotenoid pigments fulfill a number of essential roles in vision, protection from stresses, and signaling. Although carotenoids are synthesized primarily by plants and some bacteria and fungi, carotenoid biosynthetic genes have been acquired by horizontal gene transfer in some insects and mites. In the two-spotted spider mite, Tetranychus urticae , as well as in a related species, we show that a horizontally transferred carotenoid biosynthetic gene is required for normal pigmentation. Spider mites can therefore synthesize their own carotenoids. Further, in a T. urticae strain, the gene is required for the induction of diapause, a key for overwintering of this widespread and important agricultural pest.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.075
GPT teacher head0.361
Teacher spread0.286 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations126
Published2017
Admission routes2
Has abstractyes

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Same venueProceedings of the National Academy of SciencesSame topicAntioxidant Activity and Oxidative StressFrench-language works237,207