Delineation of the Molecular and Genetic Role of Teneurin C-terminal Associated Peptide-1 (TCAP-1) in Cytoskeletal Development and Neuroprotection Against Stress
Bibliographic record
Abstract
The Corticotropin Releasing Factor (CRF) peptides are an evolutionarily conserved peptide family integral to the stress response. In 2002, an investigation was undertaken into possible homologues of CRF, which led to the discovery of the Teneurin C-terminal Associated Peptide (TCAP) family located on the C-terminal end of the teneurin proteins. This peptide family is involved in neuroprotection against stress. TCAP possesses a number of biological actions independent of teneurin, however, evidence of how TCAP is processed from its proprotein had not been determined. I hypothesize that TCAP is transcribed independently and has independent functionality in promoting filopodia elongation and outgrowth. Here, I show that TCAP-1 is independently expressed as an mRNA separate from the teneurin gene. Moreover, a key step in the TCAP-1 mediated molecular mechanism of filopodia outgrowth may require an interaction between Elongation Factor-1α (EF-1α) and the actin cytoskeleton, where this mechanism is not modulated by CRF.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".