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Record W2735576184 · doi:10.1016/s2352-3018(17)30095-4

Fixed-dose combination dolutegravir, abacavir, and lamivudine versus ritonavir-boosted atazanavir plus tenofovir disoproxil fumarate and emtricitabine in previously untreated women with HIV-1 infection (ARIA): week 48 results from a randomised, open-label, non-inferiority, phase 3b study

2017· article· en· W2735576184 on OpenAlexaff
Catherine Orrell, Debbie Hagins, Elena Belonosova, Norma Porteiro, Sharon Walmsley, Vicenç Falcó, Choy Man, Alicia Aylott, Ann M. Buchanan, Brian Wynne, Cindy Vavro, Michael Aboud, Kimberly Y. Smith, Pedro Cahn, Lidia Isabel Cassetti, Norma Porteiro Barreira, Jonathan B. Angel, Alexandra de Pokomandy, Marianne Harris, Anita Rachlis, Clotilde Allavena, Oliver Bouchaud, Caroline Gatey, Agathe Rami, Salvatore Casari, Giovanni Di Perri, Adriano Lazzarin, Franco Maggiolo, Giovanni Penco, Tiziana Quirino, Giuliano Rizzardini, Jaime Andrade‐Villanueva, Juan Sierra‐Madero, Teresa Branco, Rosário Serrão, Eugénio Teófilo, Ivan Melendez-Rivera, Lizette Santiago, Carmen Zorrilla, Oksana Chernova, Vadim Pokrovsky, Aza Rakhmanova, Olga Aleksandrovna Tsybakova, Eugene Voronin, Tasneem Vally, Livhuwani ML. Farisani, Boitumelo Lucrecia Sebopa, Carlos Aguado Barros, Alfredo Cano Sánchez, Manuel Castaño, Juan González‐García, José Hernández‐Quero, Marı́a Jesús Pérez-Elı́as, Daniel Podzamczer Palter, Joaquín Portilla, Pompeyo Viciana Fernández, Weerawat Manosuthi, Kiat Ruxrungtham, David H. Dockrell, Phillip Hay, Margaret Johnson, Nicola Mackie, Chloe Orkin, Laveeza Bhatti, Indira Brar, Robert Owen Brennan, Jerry Cade, Beata Casańas, Kathleen Casey, Douglas Cunningham, Edwin DeJesus, Craig Dietz, Robin Dretler, Joseph J. Eron, Franco Antoni B. Felizarta, Kenneth H. Fife, Margaret Hoffman-Terry, Mamta K. Jain, Marc Alexander Johnson, Clifford A. Kinder, Princy Kumar, Stanley T. Lewis, Cheryl McDonald, Armando Meza, Karam Mounzer, Cheryl Newman, Olayemi Osiyemi, Ronald Poblete, Rachel M. Presti, Moti Ramgopal, Joel Rosenstock, Rafik Samuel, Uriel Sandkovsky, Alyssa Shon, Daniel J. Skiest, Louis Sloan, Catherine B. Small, Pablo Tebas, Cornelius N. Van Dam

Bibliographic record

VenueThe Lancet HIV · 2017
Typearticle
Languageen
FieldMedicine
TopicHIV/AIDS drug development and treatment
Canadian institutionsUniversity Health Network
FundersViiV Healthcare
KeywordsDolutegravirEmtricitabineMedicineAbacavirAtazanavirRitonavirLamivudineRaltegravirRegimenPopulationViral loadInternal medicineVirologyHuman immunodeficiency virus (HIV)Antiretroviral therapyVirus

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.031

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0030.002
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.002
Open science0.0010.000
Research integrity0.0020.004
Insufficient payload (model declined to judge)0.0090.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.054
GPT teacher head0.337
Teacher spread0.283 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations118
Published2017
Admission routes1
Has abstractno

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Same venueThe Lancet HIVSame topicHIV/AIDS drug development and treatmentFrench-language works237,207