Solvent Isotope Effect on Biomolecular Adsorption at Hydrophobic Surfaces
Bibliographic record
Abstract
In vibrational studies of biological systems, D 2 O is often substituted for H 2 O to more clearly resolve the amide I and C–H stretching regions. However, in interfacial studies where adsorption is involved, the difference between these two solvents may play a role in the amount adsorbed and, consequently, the adsorbed structure. Nonlinear vibrational spectroscopy reveals striking differences in the spectral signature of the hydrophobic amino acid leucine adsorbed on polystyrene in the presence of light versus heavy water. Dissipation-monitoring quartz crystal microbalance studies conclude that more amino acid is present on the hydrophobic surface when the solvent is D 2 O, and the relative surface populations account for the difference in spectral intensity. This finding has consequences for surface structural studies, and provides insight into the role of solvent in biomolecular adsorption at hydrophobic surfaces.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".