Generating 2-dimensional concentration gradients of biomolecules using a simple microfluidic design
Why this work is in the frame
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Bibliographic record
Abstract
This study reports a microfluidic device for generating 2-dimensional concentration gradients of biomolecules along the width and length of a chamber and conventional 1-dimensional gradients along the width of its lateral parallel channels. The gradient profile can be precisely controlled by the applied flow rate. The proposed design is simple and straightforward, has a small footprint size compared to previously reported devices such as tree-shape designs, and for the first time, provides capability of generating desired 2D and 1D gradients, simultaneously. The finite element simulation analysis proves the feasibility of the microfluidic device, and the fluorescently labelled IgG antibody is used to demonstrate generated chemical gradients. This simple microfluidic device can be implemented for a wide range of high-throughput concentration gradient applications such as chemotaxis, drug screening, and organs-on-chips.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it