024 Timing and frequency of antibiotic and nonsteroidal anti-inflammatory drug administration does not affect wound healing in recently weaned beef calves after band castration
Bibliographic record
Abstract
The aim of this study was to evaluate if the timing and frequency of administration of an antibiotic (oxytetracycline; 1 mg/10 kg of BW) and a nonsteroidal anti-inflammatory drug (NSAID; meloxicam, 0.5 mg/kg of BW) improved wound healing in band castrated calves. Drugs were administered as a combination. Twenty-four recently weaned Angus crossbred bull calves (292 ± 19.1 kg of BW) were randomly assigned to 1 application of antibiotic and NSAID at the time of banding (CTR); 2 applications, at banding and when the band broke through the skin (SKB); 2 applications, at banding and when the scrotum sloughed off (SSO); or 3 applications, at banding, when the band broke through the skin, and when the scrotum sloughed off (SKSO). Wound healing was assessed in all calves over a 69-d period after band placement. Indicators of wound healing included maximum scrotal area temperature (°C) assessed via infrared thermography, scrotal circumference (cm), visual evaluation of swelling (6-point scale, in which 0 = no swelling and 5 = increased degree of swelling with presence of pus), healing of the wound site (5-point scale in which 1 = incision open without scabbing and 5 = incision completely healed), and pain sensitivity (g) using a Von Frey anesthesiometer. In addition, BW (kg), ADG, and rectal temperature (°C) were recorded. Data was collected the day prior to castration; immediately before castration; 8 h after castration; on d 1, 3, 6, 13, 20, and 27; and weekly thereafter until the end of the study. Data were analyzed using a mixed-effects model, where application of antibiotic and NSAID, time, and their interactions were used as fixed effects and animal within pen was used as a random effect. On d 41 after castration, 100% of the scrotums had sloughed off. However, no differences among treatments were observed for when sloughing occurred. No differences in wound healing (P = 0.72) or swelling (P = 0.13) were observed among treatments. In addition, no treatment differences were observed for pain sensitivity (P = 0.71) after loss of the scrotum (489, 389, 366, and 380 g for CTR, SKB, SSO, and SKSO, respectively), growth (P = 0.96), or rectal temperature (P = 0.91). Repeated applications of antibiotic and NSAID after band castration did not improve healing or reduce inflammation or pain sensitivity in recently weaned beef calves.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".