Indirect MPI-based detection of superparamagnetic nanoparticles transported by computer-controlled magneto-aerotactic bacteria
Bibliographic record
Abstract
MC-1 strain magneto-aerotactic bacteria recently used in cancer therapy and labeled with superparamagnetic nanoparticles are localized by magnetic particle imaging (MPI) spectrometry. A 8.5 mT drive field oscillating at 150 kHz is generated in a solenoid coil and placed near two receiving coils connected in series in a gradiometric configuration. The magnetic behavior of superparamagnetic particles attached to the MC-1 bacteria using MC-1 antibodies allowed the indirect detection of the MC-1 bacteria. It is moreover validated that the drive field does not break the covalent bond between the MC-1 antibodies coating the superparamagnetic particles and the MC-1 bacteria. The results presented here demonstrate the usability of a MPI device to provide a real-time evaluation of the evolution of cancer treatment using MC-1 bacteria as delivery vectors.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".