Zoledronic Acid in Breast Cancer Patients with Bone Metastasis
Bibliographic record
Abstract
Background: Zoledronic acid is a nitrogen containing bisphosphonate that has been proven to reduce osteoporosis and cancer induced osteolysis. Zoledronic acid has been the treatment of choice for the prevention of skeletal complications of bone metastasis (Pain, Pathological fracture) in patients with breast cancer, which have significant impact on the quality of life of patien ts.The aim of the study is to evaluate the efficacy and tolerability of zoledronic acid in improving pain scoreand quality of life in patients with bone metastasis secondary to breast cancer.Materials & Methods: 150 patients with bone metastasis and pathologically confirmed carcinoma of the breast with ECOG PS 0-2 and adequate renal function during the period between January 2007 and January 2009 were enrolled. Treatment consisted of zoledronic acid 4 mg IV over 15 minutes repeated every 3-4 weeks concurrently with chemotherapy and/or hormonal therapy or radiotherapy if treatment was needed.Zoledronic acid was administrated continuously until worsening in the performance status, Progressionof the disease or severe adverse events. Pain was evaluated by the present pain intensity from McGill Melzack (PP1) questionnaire, quality of life (QOL) was assessed with functional assessment of cancer therapy (FACT) questionnaire.Results: The median age was 48 years (range: 30 -65 years) median PS was 1, extent of disease (metastasis): 60 patients (40%) had only one bone metastatic site and 30 patients (20%) had more than 3 bone metastatic sites. The average number of administrated cycles was 12 cycles (Range 6-50) and the average accumulated dose was 48 mg (24-200), 75 patients (50%) received treatment continuously for 2 years. The calcium and creatinine serum levels were assessed before each infusion. Five patients (3.3%) developed hypocalcaemia (calcium < 8 mg/dl) and 2 patients (1.3%) experienced a significant increase in serum creatinine (> 3 mg/dl), 12 patients (8%) had an increase of pain after first infusion of Zoledronic acid. The rate of objective reduction in pain with zoledronic acid was 48%. The improvement of qualityof Life occu red in 75 patients (50%).Conclusion: Zoledronic acid is an effective, well tolerated and easily administrated bisphosphonate with evidence of activity in the treatment of bone metastasis from breast cancer. Zoledronic acid significantly improves quality of life and pain score.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".