Promoting Angiogenesis and Neurogenesis in a Vascular Dementia Model via HIF-1 Transcriptional Repressor PRMT1
Bibliographic record
Abstract
Vascular Dementia is a complex condition often co-diagnosed with other neurodegenerative disorders. Its pathophysiology is driven by multiple factors including hypoxia which facilitates tissue death. Vascular stresses including ischemic brain lesions thereby accompany this harmful subset of dementia. PRMT1 is an arginine methyltransferase responsible for the repression of Hif-1, a hypoxia-induced cellular factor. HIF-1 in turn regulates VEGF expression, an angiogenic factor that assists with the restoration of blood vessels. Hence, targeting brain endothelial cell PRMT1 may represent a means to induce angiogenesis and downstream neurogenesis in damaged brain tissues thereby alleviating cognitive declines associated with tissue death. The in vitro and in vivo studies highlighted here present an opportunity to study a novel function of PRMT1 in Vascular Dementia.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".