Chemistry 2.0: Developing a New, Solvent-Free System of Chemical Synthesis Based on Mechanochemistry
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Mechanochemistry by grinding or milling has grown from a laboratory curiosity to a versatile approach for the synthesis and discovery of molecules, materials and reactivity. Focusing on organic synthesis and the chemistry of organic solids in general, we now provide a snapshot of this exciting, rapidly developing area, with the intention to illustrate its potential in establishing a more efficient and environmentally friendly system of chemical and materials synthesis, based on solid-state transformations rather than conventional, solution-dependent chemistry. 1 What is Chemistry 2.0? 2 Introduction 2.1 Why Mechanochemistry Now? 2.2 What’s in a Mechanochemistry Laboratory? 3 Liquid-Assisted Grinding (LAG): Controlling Mechanochemistry 4 The Solvent-Free Research Laboratory 5 Medicinal Mechanochemistry 6 Exploring Molecular Recognition 7 Some Myths to Dispel 8 Catalytic Reactions by Mechanochemistry 8.1 Catalysis and Reactivity Involving Bulk Metals 8.2 Enzyme Catalysis in Mechanochemistry 8.3 Coupling of Mechanochemistry, Photochemistry and Supramolecular Catalysis 9 Organometallic Mechanochemistry 10 New Opportunities 10.1 Stoichiometric Control 10.2 ‘Impossible’ Molecules 10.3 Reaction Discovery by Mechanochemistry 11 Energetics of Mechanochemistry 12 Mechanistic Understanding 13 Real-Time Reaction Monitoring 14 Conclusions
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it