Caloric restriction prevents the age‐related decline in cardiac complex IV activity with aging in male F344BN rats
Bibliographic record
Abstract
Objective Aerobic metabolic function declines with aging in a variety of tissues and is often manifest as a disproportionate decline in complex IV (COX) activity. Alternatively, caloric restriction (CR) enhances mitochondrial function and prevents the age‐related decline in skeletal muscles. Hypothesis CR will attenuate the age‐related decline in complex IV activity in cardiac muscle. Methods Hearts from young adult, late middle aged and senescent ad libitum (AL) and CR F344BN rats were harvested under anesthesia. COX and citrate synthase (CS) activities were assayed in the crude heart homogenate, and subsarcolemmal (SSM) and intermyofibrillar (IFM) mitochondria. Results COX activity declined significantly with aging in the crude homogenate of AL animals. COX activity was lower in CR but did not decline with aging. IFM had significantly greater COX activities than SSM regardless of age or diet. CR increased COX activity with aging in both IFM and SSM. CS activity did not change with age or diet. Conclusions CR F344BN rats have significantly lower COX activity than AL animals, but in contrast to AL maintain this activity over the lifespan, similar to results in skeletal muscle. In the isolated mitochondria, CR induced an increase in COX activity with aging. Thus a fundamental effect of CR appears to be maintained muscle oxidative capacity with aging. Supported by CIHR.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".