OP30.02: Ultrasound and MRI abnormalities of fetal cortical plate morphology correlate with development of cerebral malformations
Bibliographic record
Abstract
The cortical plate is a transient structure which develops as a result of neuronal precursor migration from the germinal matrix and ganglionic eminence. It gives rise to the future cerebral cortex. The objective of this study is to examine abnormal cortical plate morphology, as a predictor of aberrations of neuronal migration and cerebral cortical development. Images of the cortical plate were documented in 30 normal fetuses in the second trimester to establish normative values. Normal imaging findings were compared with 20 cases in which the cortical plate appeared abnormally thick, thin, or irregular in appearance. Images from 8 cases were analysed prospectively and 12 were reviewed retrospectively. Imaging findings were compared with postmortem or postnatal imaging diagnoses. Normal cortical plate thickness ranged from 1 mm in the early second trimester to 3 mm at the beginning of the third trimester. The surface of the cortical plate and interface with the underlying subplate appeared well-defined and smooth. Among 20 fetuses with suspected brain pathology, an abnormally thick and irregular cortical plate was identified in 6 fetuses, thought to be predictive of polymicrogyria. Subsequent pathological or postnatal imaging examination showed evidence of polymicrogyria or pachygyria in 5/6 cases. There was one false positive diagnosis of polymicrogyria, in a fetus with additional intracranial anomalies. A diffusely thickened, irregular, and poorly defined cortical plate was documented in 4 cases of Type II lissencephaly. Diffuse thinning of the cortical plate was identified in 4 cases of type 1 lissencephaly. Abnormally located focal indentations of the cortical plate predicted abnormal sulcation in 6 cases. Prenatal ultrasound examination of the cortical plate in the second trimester allows recognition of aberrant migration abnormalities and predicts possible ensuing cerebral malformations.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".