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Record W2756281840 · doi:10.1016/j.ddmod.2017.08.002

Genome wide conditional mouse knockout resources

2016· article· en· W2756281840 on OpenAlexafffund
Cornelia Kaloff, Konstantinos Anastassiadis, Abdel Ayadi, Richard Baldock, Joachim Beig, Marie‐Christine Birling, Allan Bradley, Steve D.M. Brown, Antje Bürger, Wendy Bushell, Francesco Chiani, Francis S. Collins, B. G. Doe, Janan T. Eppig, R H Finnel, Colin Fletcher, Paul Flicek, Martin Fray, Roland H. Friedel, Alessia Gambadoro, Hilary Gates, Jens Hansen, Yann Hérault, Geoffrey G. Hicks, Andreas Hörlein, Martin Hrabě de Angelis, Vivek Iyer, Pieter J. de Jong, Gautier Koscielny, Ralf Kühn, P. Liu, K. C. Kent Lloyd, R. Lopez, Susan Marschall, Santiago Martínez‐Lumbreras, Colin McKerlie, Terrence F. Meehan, Harald von Melchner, Mark W. Moore, Stephen A. Murray, András Nagy, Lmj Nutter, Guillaume Pavlovic, Ana Pombero, Haydn M. Prosser, Ramiro Ramírez‐Solis, Martin Ringwald, Barry P. Rosen, Nadia Rosenthal, Janet Rossant, Edward J. Ryder, William C. Skarnes, Joel Schick, Frank Schnütgen, Paul N. Schofield, Claudia Seisenberger, Mohammed Selloum, Damian Smedley, Elizabeth M. Simpson, A. Francis Stewart, Lydia Teboul, Giovanna Valentini, D Valenzuela, Alina Nico West, Wolfgang Wurst

Bibliographic record

VenueDrug Discovery Today Disease Models · 2016
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCRISPR and Genetic Engineering
Canadian institutionsUniversity of British ColumbiaBC Children's HospitalToronto Centre for PhenogenomicsSickKids FoundationMount Sinai HospitalUniversity of Manitoba
FundersNational Human Genome Research InstituteNational Institutes of HealthCentre National de la Recherche ScientifiqueUniversité de StrasbourgInstitut National de la Santé et de la Recherche MédicaleAgence Nationale de la RechercheEuropean CommissionGenome British ColumbiaGenome Canada
KeywordsConditional gene knockoutGenomeComputational biologyGeneticsBiologyKnockout mouseComputer scienceGenePhenotype

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.226
Threshold uncertainty score0.642

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.242
Teacher spread0.235 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations7
Published2016
Admission routes2
Has abstractno

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