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Record W2757138218

HUMAN GENOME PROJECT

2005· article· en· W2757138218 on OpenAlexaboutno aff
Hetal B. Gavit

Bibliographic record

Venuenot available
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Bioinformatics, and Biomedical Research
Canadian institutionsnot available
Fundersnot available
KeywordsHuman genomeInternational HapMap ProjectGenome projectGenomeReference genomeGovernment (linguistics)BiologyDNA sequencing1000 Genomes ProjectLibrary scienceGeneticsComputational biologyGeneComputer scienceSingle-nucleotide polymorphism
DOInot available

Abstract

fetched live from OpenAlex

The Human Genome Project (HGP) was an international scientific research project with a primary goal to determine sequence of chemical base pairs which make up DNA and to identify and map approximately 20,000–25,000 genes of human from both a physical and functional standpoint. The first available assembly of was completed in 2000 by UCSC Genome Bioinformatics Group, composed of Jim Kent (then a UCSC graduate student of molecular, cell and developmental biology), Patrick Gavin, Terrence Furey and David Kulp. The project began in 1990, initially headed by James D. Watson at U.S. National Institutes of Health. A working draft of was released in 2000 and a complete one in 2003, with further analysis still being published. A parallel project was conducted outside of government by Celera Corporation. Most of government-sponsored sequencing was performed in universities and research centers from United States, United Kingdom, Canada, and New Zealand. The mapping of human genes is an important step in development of medicines and other aspects of health care. The HGP originally aimed to map nucleotides contained in a haploid reference human (more than three billion). Several groups have announced efforts to extend this to diploid human genomes including International HapMap Project, Applied Biosystems, Perlegen, Illumina, JCVI, Personal Genome Project, and Roche-454. The of any given individual (except for identical twins and cloned organisms) is unique; mapping the human genome involves sequencing multiple variations of each gene. The project did not study entire DNA found in human cells; some heterochromatic areas (about 8% of total genome) remain un-sequenced.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.189
Threshold uncertainty score0.631

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.010
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0050.009
Science and technology studies0.0020.001
Scholarly communication0.0030.002
Open science0.0030.003
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.1890.119

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.318
Teacher spread0.293 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2005
Admission routes1
Has abstractyes

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