147: Early Results of National Surveillance of Childhood Tuberculosis in Canada
Bibliographic record
Abstract
There is little detailed epidemiologic and clinical data about tuberculosis (TB) disease in children in Canada. To characterize the epidemiologic, clinical, and treatment data for all cases of TB in children under age 15 in Canada through the Canadian Pediatric Surveillance Program's (CPSP) Childhood Tuberculosis Study. The initial results of the three year study presented here includes cases from September 2013 to October 2014. TB cases were identified through a monthly form sent by the CPSP to approximately 2500 active pediatricians, pediatric subspecialists, and select non-pediatricians who manage childhood TB. For cases meeting inclusion criteria, a detailed questionnaire was sent to collect clinical, epidemiological, and treatment data, followed by 6-month follow-up surveys until six months after treatment completion. Of 70 unique incident cases reported, 34 cases both met inclusion criteria and returned a detailed questionnaire. Selected demographic data is shown in Table 1. Intrathoracic TB was reported in 32/34 (94%) of cases including 26 with pulmonary infection. One or more positive cultures were obtained in 13/27 (48%) of cases attempting pulmonary culture using sputum (n=7), bronchoalveolar lavage (n=1), and/or gastric aspirates (n=6). Of these, 4/12 (33%) were positive in patients younger than 5 years, 2/6 (33%) between ages 5–9, and 7/9 (78%) children 10+ years. No culture-negative specimen had a positive AFB, PCR, or AMTD. Extrathoracic TB was reported in 27% (n=9). Of these, seven cases had central nervous system involvement. One case had confirmed drug resistance to Isoniazid and Rifampicin. Numerous cases of childhood TB in Canada have been identified through early results from the CPSP Childhood Tuberculosis Study and detailed clinical, epidemiological, and treatment data have been obtained on these cases. This study will provide the most complete picture of childhood TB in Canada and will serve to refine practice in monitoring, detecting, and treating this infection.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.004 |
| Science and technology studies | 0.002 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".