79: Hypoglycemia in Full-Term Newborns with No Pre-Identified Risk Factors
Bibliographic record
Abstract
Monitoring protocols are used for early detection of hypoglycemia in at-risk term newborns such as infants of diabetic mothers, those with growth restriction or macrosomia and infants with acute neonatal illness. Universal glucose monitoring is not recommended since benign transient hypoglycemia occurs in up to 14% of healthy term newborns. Clinically significant hypoglycemia is felt to be uncommon in newborns with no known risk factors. However, unmonitored newborns who do become hypoglycemic often have a delay in diagnosis and treatment as onset of symptoms may be the indication to measure blood glucose. To determine the prevalence of significant hypoglycemia amongst full term newborns with no pre-identified risk factors in a regional centre. We reviewed the charts of newborns born at 37 to 42 weeks, birthweight 2500 g to 3999 g with documented hypoglycemia at a regional centre over a three year period. We focussed on those with a glucose level of <2.0 mmol/L and requiring IV dextrose. Infants of mothers with gestational and pre-gestational diabetes were excluded as were infants with birth depression, transient respiratory distress and those with acute illness. From a population of 6272 term newborns we identified eight hypoglycemic infants who met the criteria. Four of the newborns were less than the10th centile for weight and one baby had Down Syndrome. Of the remaining three hypoglycemic infants the first presented at 26 h of life with jitteriness. Blood glucose was 1.3 mmmol/L. Hypoglycemia resolved three days later. Polycythemia was noted. Mother was obese and hypertensive. The second case presented with jitteriness at 60 h of life with blood glucose 1.5 mmol/L. Hypoglycemia resolved a day later. No diagnosis was made. Mother was obese. The third case presented at 13 h with jitteriness and blood glucose 0.3 mml/L. He subsequently had three seizures. Hypoglycemia resolved six days later. The diagnosis was transient hyperinsulinism. Mother was hypertensive. Use of <10th centile weight parameter, as recommended by the CPS, is superior to an arbitrary weight cut-off in identifying growth-restricted term newborns who may be at risk of hypoglycemia. A small number of normal birth weight newborns fall outside current monitoring recommendations yet have clinically significant hypoglycemia. Many of these infants do not have a chronic underlying metabolic or endocrine disorder. We recently launched a Canadian Pediatric Survellance Program project to determine incidence of hypoglycemia in term newborns without pre-identified risk factors, to document presentation and early morbidity and to obtain clues about unrecognized or underappreciated risk factors.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".