89: Early Postnatal Exposure to Oxidants Induces Prolonged Oxidative Stress and Increases the Incidence of Oxidative Stress Related Diseases in Preterm Infants les Less than 29 Weeks Gestational Age
Bibliographic record
Abstract
In preterm infants, the antioxidant defenses are still poorly developed. The two major sources of oxidants during intensive care stay are oxygen and parenteral nutrition (PN) which is contaminated with peroxides. We hypothesize that early O2 supplementation and longer PN duration increase the risk for oxidative stress associated diseases such as bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC). To assess the effect of early oxygen (on day 7 and 28) and the PN duration on oxidative stress markers at 36 weeks corrected age and on oxidative stress related diseases. A prospective observational study including all infants <29 weeks GA without major congenital anomalies admitted to our NICU during one year period (116 infants). During the first week of life, in fifty-one out of 116 infants, consent for blood sample at 36 corrected age (CA) was obtained. GSH and GSSG (nmol/mg protein) were measured by capillary electrophoresis and were used for redox potential (mV) calculation using Nernst equation -expressed as mean (sem). BPD was defined as the need of O2 supplement at 36 weeks CA. Significant ROP was defined as any ROP stage 3 or higher or that required laser or anti-VEGF treatment. Cases of NEC grade 2 or higher according to Bell's criteria were included. Student's t test or χ2 were used, as appropriate, *=P<0.05, **=P<0.01. Basline chracteristics was similar in the consent group and the whole cohort. FiO2 ≥25 on day 7 and 28 of life and PN duration >14 days resulted in higher GSSG concentration and more oxidized redox potential at 36 weeks CA indicating prolonged oxidative stress. FiO2 ≥25 early on life and PN duration >14 days increased the incidence of BPD, significant ROP and NEC (Table 1). Early life exposure to oxidants is associated with prolonged oxidative stress and higher incidence of oxidative stress-related diseases. These results suggest that strategies targeting judicious O2 use and either decreasing the duration or using safer formulation PN will help decreasing the incidence of BPD, ROP and NEC.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".