RESULTS OF NATIONAL SURVEILLANCE OF CHILDHOOD TUBERCULOSIS: 2013–2016
Bibliographic record
Abstract
BACKGROUND: There is little detailed epidemiologic and clinical data about tuberculosis (TB) disease in children in Canada. OBJECTIVES: This study characterizes the epidemiologic, clinical, and treatment data for all cases of TB in children under age 15 in Canada surveyed through the Canadian Pediatric Surveillance Program’s (CPSP) Childhood Tuberculosis Study. Preliminary results from the study from October 2013 to September 2016 are presented here, as data collection from reported cases is still ongoing. DESIGN/METHODS: New active TB cases were identified through a monthly form sent by the CPSP to approximately 2500 active pediatricians, pediatric subspecialists, and select non-pediatricians who manage childhood TB. For cases meeting inclusion criteria, a detailed questionnaire was sent to the treating physician to collect clinical, epidemiological, and treatment data, followed by 6-month follow-up surveys until 6 months after treatment completion. RESULTS: Of 248 unique incident cases reported, 142 cases both met inclusion criteria and returned a detailed questionnaire. Selected demographic data are shown here: Intrathoracic TB was reported in 129/142 (91%) of cases of which 111 had pulmonary disease. Of 104 patients who underwent investigations for pulmonary disease (sputum in 60, brochoalveolar lavage in 6, and gastric aspirates in 56), one or more positive cultures were obtained in 42 (40%). Within age groups, the proportion of cases who underwent investigation for pulmonary disease and were culture positive was: 3/11 (27%) under 1 year of age, 14/40 (35%) 1-4 years old, 8/23 (35%) 5-9 years old, and 17/30 (57%) 10 years or older. Extrathoracic TB was reported in 35 (25%), including 16 (42%) patients 10+ years old. There was one case of multi-drug resistant TB. CONCLUSION: Preliminary results from this study suggests a high incidence of TB in Inuit and First Nations children, as well as a higher proportion of extrathoracic TB and greater success in culture positivity in children aged 10+. At completion, this study will provide the most complete picture of childhood TB in Canada and will serve to refine practice in monitoring, detecting, and treating this infection.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.003 | 0.004 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".