Binding Modes and Reactivity of Pyrido[2,1-<i>a</i>]isoindole as a Neutral Carbon Donor with Main-Group and Transition-Metal Elements
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Bibliographic record
Abstract
High Resolution Image Download MS PowerPoint Slide Various binding modes of pyrido[2,1- a ]isoindole with main-group and transition-metal elements have been established. The carbon atom at position 6 of pyrido[2,1- a ]isoindole is highly nucleophilic, forming a σ complex with Pt(II) ion. The benzene ring of pyrido[2,1- a ]isoindole forms an η 6 -π complex with Cr(0). The reaction of pyrido[2,1- a ]isoindole with PPh 2 Cl in the presence of Proton Sponge leads to a PPh 2 -functionalized product, which can further react with a BH 3 molecule, forming a P→B adduct. Pyrido[2,1- a ]isoindole was also found to undergo a dehydrogenative C–C coupling reaction in the presence of Cu(I) ions, forming a dimer. These interesting reactivities and binding modes demonstrate the rich chemistry of pyrido[2,1- a ]isoindole, as well as its potential application in main-group and transition-metal chemistry.
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Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
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Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it