P2080Cardiopulmonary, vascular and biomarker responses to acute hypoxic stress following cardiac transplantation
Bibliographic record
Abstract
Background: A few case studies have shown good adaptation of cardiac transplant (CTx) recipients to exposure to a high altitude environment. No studies have investigated the cardiovascular, pulmonary, and biomarker responses to acute hypoxic challenges both at rest and in response to sub-maximal exercise in long-term cardiac transplant recipients. Methods: Thirty-six CTx recipients 8.8±7.6 years after transplantation and seventeen age-matched healthy controls (HC) were recruited. Seventeen CTx patients (42%) presented cardiac allograft vasculopathy (CAV), thirteen of grade 1 (87%) and two of grade 2 (13%). Ventilatory and cardiovascular responses to maximal and submaximal exercise in normoxic conditions, following to 20-min normobaric hypoxia and after 10 minutes hypoxic challenge using 30% submaximal load at 11.5% oxygen (02) were performed. Endothelial peripheral function was assessed at 21% 02 using near-infrared spectroscopy. Biomarkers including vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) and suppression of tumorigenicty 2 (ST2) were measured at baseline and at peak stress.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".