56 Outcome of Neonates Less than 30 Weeks with Histological Chorioamnionitis
Bibliographic record
Abstract
To determine the short term outcome of newborns less than 30 weeks gestation when there is definite placental histological chorioamnionitis. Retrospective analysis of records of all neonates delivered at our institution from Jan 1989 through to Jan 1999. This information was retrieved from our perinatal database and pathology database. The population was stratified according to the presence or absence of histological chorioamnionitis. Statistical analysis was performed using Student's t test and Mann Whitney. Logistic regression was used to control for potential confounding variables. There were 392 neonates less than 30 weeks delivered during this time period. Complete placental histology was available on 342 patients (87.4%). Histological chorioamnionitis was identified in 140 (40.9%) cases. Those with histological chorioamnionitis delivered sooner (26.3 weeks versus 27.5 weeks), were of lower birth weight (920.1 grams versus 1029.8 grams ) and had lower 5 min apgars. Neonatal septicaemia and pneumonia were strongly associated with underlying histological chorioamnionitis. Neonatal septicaemia occurred in 10.7% of live births where there was a diagnosis of severe histological chorioamnionitis (versus 1.5% without p<0.05). The organisms most commonly isolated were group B strep, E. coli and Candida albicans. All cases of septicaemia had received antepartum antibiotics. There was a significant reduction in the odds of developing RDS ( OR 0.43, p value 0.001) and odds of dying in the neonatal period (OR 0.38, p value 0.001) when histological chorioamnionitis was present. Severe histological chorioamnionitis increases the risk of premature delivery and is strongly associated with neonatal sepsis. There is a significant reduction in the incidence of RDS and neonatal mortality in patients with histological chorioamnionitis .
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".