siRNAzos: A New Class of Azobenzene‐Containing siRNAs that Can Photochemically Regulate Gene Expression
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Fine‐tuning the activity of short‐interfering RNAs (siRNAs) with light could help overcome several obstacles related to potency, delivery, and off‐target effects. In this study, we chemically modify siRNAs that contain azobenzene derivative spacers within the sense strand. These molecules are called siRNAzos and they are successfully accommodated within the RNAi pathway as measured by gene‐silencing dose‐dependent knockdown. In addition to its RNAi biocompatibility, we are able to photochemically control the activity of the siRNAzos that contain the azobenzene within the central region of the sense strand. We demonstrate it is possible to both inactivate and reactivate several siRNAzos with ultraviolet and visible light, respectively.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it