The challenge of mapping the human connectome based on diffusion tractography
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Abstract
Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent). However, the same tractograms contain many more invalid than valid bundles, and half of these invalid bundles occur systematically across research groups. Taken together, our results demonstrate and confirm fundamental ambiguities inherent in tract reconstruction based on orientation information alone, which need to be considered when interpreting tractography and connectivity results. Our approach provides a novel framework for estimating reliability of tractography and encourages innovation to address its current limitations.
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The record
- Venue
- Nature Communications
- Topic
- Advanced Neuroimaging Techniques and Applications
- Field
- Medicine
- Canadian institutions
- MaRSWestern UniversityHôpital du Sacré-Cœur de MontréalSynaptive (Canada)Institut Universitaire de Gériatrie de MontréalUniversity of TorontoUniversity Health NetworkUniversité de MontréalUniversité de Sherbrooke
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Biomedical Imaging and BioengineeringNatural Sciences and Engineering Research Council of CanadaCentre d'Imagerie BioMédicaleNational Natural Science Foundation of ChinaNational Institutes of HealthSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungÉcole Polytechnique Fédérale de LausanneDeutsche ForschungsgemeinschaftChina Scholarship CouncilNational Institute for Health and Care ResearchNederlandse Organisatie voor Wetenschappelijk OnderzoekWellcome TrustNational Cancer InstituteUniversité de SherbrookeNational Science Foundation
- Keywords
- ConnectomeTractographyDiffusion MRIHuman Connectome ProjectConnectomicsComputer scienceNeuroscienceDiffusionComputational biologyFunctional connectivityMedicineBiologyMagnetic resonance imagingPhysicsRadiology
- Has abstract in OpenAlex
- yes