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Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial
Miguel Martín, Frankie A. Holmes, Bent Ejlertsen, Suzette Delaloge, Beverly Moy, Hiroji Iwata, Gϋnter von Minckwitz, Stephen Chia, Janine Mansi, Carlos H. Barrios, Michael Gnant, Z. Tomasevic, Neelima Denduluri, Robert Šeparović, Erhan Gökmen, Anna Bashford, Manuel Ruíz Borrego, Sung‐Bae Kim, Erik Jakobsen, A. Ciceniene, Kenichi Inoue, Friedrich Overkamp, Joan B. Heijns, Anne Armstrong, John S. Link, Anil A. Joy, Richard Bryce, Alvin Wong, Susan Moran, Bin Yao, Feng Xu, Alan Auerbach, Marc Buyse, Arlene Chan, Vernon Harvey, Rudolf Tomek, Nicholas J. Robert, Ira Gore, John W. Smith, Norikazu Masuda, S. Di Sean Kendall, William Graydon Harker, Katarína Petráková, Ángel Guerrero‐Zotano, Amparo Ruiz Simón, Zora Neskovic Konstantinovic, Nicholas Iannotti, Pierfrancesco Tassone, Gladys Rodriguez, Noelia Jáñez Martínez, Carmen Crespo Massieu, Snezana Smickoska, Işıl Somali, Uğur Yılmaz, Mirta Garcia Alonso, Adolfo Rosales, Soeren Cold, Ann Knoop, Debra A. Patt, Beth A. Hellerstedt, Ingrid A. Mayer, Julie A. Means‐Powell, Rina Hui, Francis M. Senecal, Richard Hendry De Boer, Zhenzhou Shen, A.A. Luczak, Joanna W.Y. Chui, Janice Tsang, István Láng, Yoshiaki Rai, Yasuo Hozumi, Albert J. ten Tije, Manish Bhandari, Cynthia R. Osborne, Shoichiro Ohtani, Kenji Higaki, Kenichi Watanabe, Kazunori TAGUCHI, Masato Takahashi, Sladjana Filipovic, Vincent Hansen, Vijayarama Phooshkooru Rao, Manish Gupta, Petar Petrov, Bruno Coudert, Željko Vojnović, Zsofia Polya, Toshiko Miyaki, Naohito Yamamoto, Stephen Brincat, Krzysztof Leśniewski-Kmak, Ewa Chmielowska, Ruemu Birhiray, Marc L. Citron, Steven W. Papish, William L. Berry, Sven Tyge Langkjer, José Á. García-Sáenz, Ana Arance, Noa Efrat, Tomasz Sarosiek, Lukasz Grzeda, Yvonne Manalo, Julie C. Smith, Irfan Vaziri, Tabitha Healey, Yasmin Rahim, Cynthia T. Luk, B. Dingle, Sandra Franco, Peter G. Sørensen, Anjana Anand, Sarah Khan, George Fountzilas, Kenjiro Aogi, Satoru Shimizu, Milada Mikulova, S. Špánik, Robert A. Somer, Patrick J. Flynn, Jermaine Coward, Paul N. Mainwaring, Guy Jérusalem, Carine Segura-Ojezzar, Christelle Lévy, T. Delozier, David Khayat, Robert E. Coleman, Martin Rolles, R. Maisano, Mario Nardi, Yoshinori Ito, Perran Fulden Yumuk, Gül Başaran, Nazım Serdar Turhal, Mary Wilkinson, Nathan B. Green, Algis P. Sidrys, Sigrun Hallmeyer, Douglas J. Testori, Srikala S. Sridhar, José Chang, Qiang Sun, Carlos Jara-Sánchez, Xabier Mielgo-Rubio, María Lomas Garrido, Juan de la Haba-Rodríguez, A. Perelló Martorell, Antoni Mestre, Julio Rifa Ferrer, Sonia Del Barco Berrón, Zsuzsanna Nagy, Maki Tanaka, Young‐Hyuck Im, Robert R. Carroll, Laura C. Dickerson, Joseph R. Mace, Ragene Rivera, Leonard M. Klein, Robert L. Ruxer, Sharon Wilks, Dusan Kotasek, Vasil Popov, V. Taskova, Violetka Marinova-Venkova, Constanta Timcheva, Christine Desbiens, Jean-Pierre M. Ayoub, Debjani Grenier, Norbert Marschner, Hans Tesch, Hans-Joachim Lueck, Jan Janßen, Ingo Schwaner, Stine Wahlstrøm, Eva Brix, Susanne Vallentin, Dan Kristensen, Anna Andreeva, Vesna Glavicic, Isabel Calvo Plaza, A. Antón Torres, Corinne Veyret, Jean‐Pierre Bergerat, Emmanuelle Bourbouloux, Wendy Ann Ella, Hafiz Algurafi, A. Robinson, Seung Jin Kim, Tetsuya Taguchi, Elona Juozaitytė, Stanley Madretsma, Sandra A. Radema, Malgorzata Czerniawska-Meier, Wojciech Rogowski, Mária Wagnerová, Donald Richards, Elizabeth Tan-Chiu, Asskikis Vasileios, Charles Henderson, Viran Holden, Xiaojia Wang, Zhongsheng Tong, Junlan Yang, Manuel González, Mahdi Rezai, John Hackmann, Eduardo Martínez de Dueñas, B. Bermejo De Las Heras, Louis Marie Dourthe, Dorothée Chocteau-Bouju, Philippe Bougnoux, Stylianos Kakolyris, Haralabos P. Kalofonos, D. Pectasidis, Ting Ying Ng, Gábor Pajkos, Eva Ezer Somogyine, Giuseppe Tonini, Dario Giuffrida, Shintaro Takao, Makoto Ishitobi, Hideo Inaji, Yutaka Tokuda, Katarzyna Woźniak, Dan Lungulescu, Yen‐Shen Lu, King‐Jen Chang, Julian B. Hill, C. Croot, A. Dekker, Neil D. Belman, Miguel Á. Conde, Richard A. Michaelson, Kathleen Kemmer, Jane Yuet Ching Hui, Shiuh‐Wen Luoh, Kenneth Nahum, Andrew Greenspan, Joni C. Nichols, Carlos A. Encarnacion, Thomas M.J. Niederman, Theresa M. Lee, R. W. Alexander, Robert Gordon, A Tomová, Daniel Rauch, Răzvan Popescu, Gustavo Adolfo Rojas, J Vaňásek, Tanja Neunhoeffer, Jana Barinoff, Gerd Graffunder, Wolfgang Abenhardt, Peter Bojko, Bernhard Heinrich, Albert von der Assen, Bogovic Jurij Antonovic, Lene Adrian, Manuel Ramos Vázquez, Santiago González Santiago, Véronique Dièras, Jill Mercia Bishop, Timothy Perren, Ioannis Varthalitis, Dimitris Mavroudis, Vassilis Georgoulias, Louis WC Chow, Chung Cheung Thomas Yau, Raymond Liang, Béla Pikó, Agnes Wéber, Bella Kaufman, Karen Drumea, Francesco Nuzzo, A. De Matteis, Giacomo Cartenì, Eriko Tokunaga, M. Ishida, Shinji Ohno, Nobuaki Sato, Katsumasa Kuroi, Reiki Nishimura, Junichiro Watanabe, Yoon Ji Choi, Kyong Hwa Park, Marek Z. Wojtukiewicz, Jacek Jassem, Niklas Loman, Sercan Askoy, M. Kadri Altundağ, Pınar Saip, Muhammad Amjad Ali, James L. Wade, A. Jo Chien, Debra Brandt, Yelena Novik, Chirag Jani, Robert Rice, Yousuf Gaffar, Mark Keaton, Rajesh Bajaj, Gretchen Kimmick, David L. Campbell, Theodore Turnquest, Sideras Lucas, Pierre Dubé, Binghe Xu, J Schilling, Klaus Apel, Peter Michael Vestlev, Brita B. Jensen, Vera Haahr, Álvaro Rodríguez Lescure, C. Saura Manich, Jean-Philippe Jacquin, Ahmed Samreen, Ion Boiangiu, Magdolna Dank, Cristina Falci, Antonio Jirillo, Saverio Cinieri, Takayuki Ueno, Fumiaki Sato, Hiroyasu Yamashiro, Tomoharu Sugie, Keun Seok Lee, Jung Sil Ro, In Hae Park, Anita Zarina Bustam, Małgorzata Suszko-Każarnowicz, A. Piktel, Krzysztof Krzemieniecki, Polizenia Georgeta Iorga, Yoon Sim Yap, M. Kakalejcik, Alper Sevinc, Mustafa Özgüroğlu, Shin‐Cheh Chen, Richard H. Greenberg, Allan Daniel Eisemann, Robert Droder, Mustafa Abbasi, Marina Vaysburd, Humberto Caldera, Barbara Haley, Erwin Robin, Roger Inhorn, David Hufnagel, Peter Kenyon, Ellen N. Spremulli, Paula Silverman, Sharad Jain, Robert T. Weigand, Jeroen Mebis, Tatyana Koynova, Bernard Lespérance, Jana Prausová, Claus‐Henning Köhne, Andreas Schneeweiß, Christian Jackisch, Stefan Fuxius, Ricardo Cubedo Cervera, Ander Urruticoechea Ribate, J. V. Álvarez Gallego, Angels Arcusa Lanza, María del Pilar Álvarez, Jesús Florián Gericó, Laurent Cany, Justin Stebbing, Dejan Labudovic, Damir Gugić, Damir Vrbanec, Fausto Roila, Sandro Barni, Paolo Bidoli, Hirofumi Mukai, Vanessa Bermudez, Alexandru Eniu, B. Mirtsching, Emad Ibrahim, Joan E. Trey, Paul Hergenroeder, Aftab Mahmood, Anneliese Gonzalez, Edward H. Kaplan, Stacy Ban, Dhimant Patel, Billy Clowney, Karen Hoelzer, Garry Schwartz, Mohamed Salkeni, Jame Abraham, Sunil Narula, Khaled W. Jabboury, Robert S. Mocharnuk, Richard H. McDonough, David Sikes, Ronald H. Kawanchi, Larry Schlabach, Samuel S. McCachren, Thomas M. Cosgriff, Luke Dreisbach, Angela DeMichele, L. Pawl, Jennifer Lucas, Lowell C. Shinn, Nabiel Alkhouri, Manish Monga, Deborah Lindquist, T Anderson, Humera Khurshid, Sabrina Witherby, Nicholette Erickson, Ann Traynor, Ron Bose, Timothy Pluard, Michael Jones, Sucharu Prakash, Fabio Volterra, Gerardo Capo, Lawrence E. Flaherty, Elaina M. Gartner, Said Baidas, Ian J. Okazaki, Bichlien Nguyen, Thomas J. Rakowski, Ira A. Oliff, Joseph W. Leach, Daniel M. Anderson, Kendra Kubiak, Michaela L. Tsai, Philippe Vroman, Ines Deleu, Willem Lybaert, Marleen Borms, Félix Couture, Jonathan J. Wilson, Gordon C. Hunt, David R. Holland, Walter Mingrone, Shusen Wang, Donggeng Liu, Zefei Jiang, V. Benešová, Martin Šmakal, Petra Garnolova, Anne‐Sophie Vesper, Monika Neumann, Wolfgang Janni, Cornelia Liedtke, Dorothea Fischer, Eva‐Maria Grischke, Dietmar Seeger, Volker Moebus, A. Prechtl, Juan Carlos Camara Toral, Alfonso Sánchez Muñoz, Sonia Gonzalez Jimenez, Beatriz Cirauqui, Mireia Margelí Vila, Norberto Batista López, José Ignacio Chacón, Miguel Angel de la Cruz Mora, Audrey Mailliez, Laurence Vanlemmens, Damien Pouessel, Marc Espié, John Conibear, Rebecca Roylance, Adrian Harnett, David Geffen, Enzo Maria Ruggeri, Teresa Gamucci, Cees J. van Groeningen, Renata Banaś, Niklas Loman, Necati Alkış, Ming‐Feng Hou, Amy Krie, Nandagopal Vrindavanam, Orion M. Howard, Dennis L. Citrin, Mark Morginstin, Ajit Desai, Ines J. Sanchez, David Allen Nixon, Patrick G. Beatty, Kathryn Edmiston, Marilyn McLaughlin, J.D. Eneman, Cynthia A. Lynch, Edward R. O’Brien, Justin Call, Keith S. Lanier, Alison Conlin, Donald Brooks, Kristi McIntyre, Marc Saltzman, Michael Castine, Gregory L. Ortega, Young Choi, Craig H. Reynolds, Frankie Ann Brescia, Rita Kramer, Aimee D. Kohn, John P. Micha, Jessica Rhee, Satish Shah, David Riseberg, W. K. Patterson, Jean-Paul Salmon, Chantal André, Alain Bols, Randal D’hondt, Sylvie Luce, Claire Nouwynck, Gino Pelgrims, Vincent R. Richard, Johan Verschuere, Kurt Geldhof, Clemens B. Caspar, Rongcheng Luo, Otakar Bednařík, Kathrin Schwedler, Marcus Schmidt, Romy Neumeister, Joachim Bischoff, Brigitte Rack, Roland Repp, Stefan Fries, Ralf Adrion, Volkmar Schulz, Peter Klare, M. Danei, Dirk P Ossenbühl, Jakob Manfred Kusche, Frank Griesinger, José Manuel Baena Cañada, Purificación Martínez del Prado, D. Machover, Didier Mayeur, Nathalie Trufflandier, Valérie Delecroix, Mireille Mousseau, Marie‐Ange Mouret‐Reynier, Jean‐Marc Nabholtz, A.D. Chetiyawardana, Christos N. Papandreou, Lajos Hornyák, Zsolt Faluhelyi, Erzsebet Simo, Mario Di Palma, Francesco Cognetti, G. Gorzegno, Luigi Dogliotti, Cesare Gridelli, Alfredo Falcone, Héctor Soto Parrà, Calogero Buscarino, Seock‐Ah Im, Benito Sanchez Llamas, Wouter Dercksen, Franciscus Erdkamp, Jan B. Ruit, Hans J. Braun, J. Portielje, Aydın Çiltaş, Süleyman Buyukberber, Mustafa Beneklı, Andrew J. Zahalsky, Rebecca Jaslow, Gary W. Thomas, Archana Maini, Israel Wiznitzer, Ali Khojasteh, Manuel F. Gonzalez, Lynn R. Kong, Aruna Padmanabhan, William A. Conkright, Sandra M. Swain, Douglas Faig, Kirti Jain, Ronald Yanagihara, Yvonne Ottaviano, Andrew Delmas, Heather A. Steele, Gordon K. Rainey, Penelope J. Harris, Jason K. Burris, Erik J. Rupard, E.Z.Z. Tan, Pat W. Whitworth, A. Bova, Ian C. Anderson, Mihran Shirinian, C Tin-U, Timothy J. O’Rourke, Michael S. Roberts, Michael Francisco, A. Scott Pierson, Peter D. Byeff, Peter A. Kovach, J. R. Caton, Mark U. Rarick, William G. Schimidt, Alison Stopeck, Rachel Swart, Maria Regina Carrillo Flores, Carlos Alemany, Brennely Lozada, Paul L. Weinstein, Wei Wang, Michael Porubcin, David M. Ellison, George F. Geils, Edgardo Rivera, Mahmoud Charif
Bibliographic record
VenueThe Lancet Oncology · 2017
Typearticle
Languageen
FieldMedicine
TopicHER2/EGFR in Cancer Research
Canadian institutionsUniversity of AlbertaBC Cancer Agency
FundersNational Institute for Health and Care ResearchPuma Biotechnology
KeywordsMedicineNeratinibTrastuzumabInternal medicineBreast cancerOncologyClinical endpointPlaceboRegimenMetastatic breast cancerAdverse effectCancerClinical trialPathology
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.019
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.005 | 0.004 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.003 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.005 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.099
GPT teacher head0.462
Teacher spread0.363 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations589
Published2017
Admission routes1
Has abstractno