Record W2769105409 · doi:10.2337/dc16-2523

Impact of Excessive Weight Gain on Cardiovascular Outcomes in Type 1 Diabetes: Results From the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study

2017· article· en· W2769105409 on OpenAlex

Jonathan Q. Purnell, Barbara H. Braffett, Bernard Zinman, Rose Gubitosi‐Klug, William I. Sivitz, John P. Bantle, G. Ziegler, Patricia A. Cleary, John D. Brunzell, David M. Nathan, O. Crofford, Saul Genuth, J. Brown-Friday, Jill P. Crandall, H. Engel, Samuel S. Engel, Helen Martinez, Mark Phillips, M. Reid, Harry Shamoon, J. Sheindlin, Laurel Mayer, S. Pendegast, Hernando Zegarra, David Miller, Lawrence J. Singerman, Sheila Smith-Brewer, M. NOVAK, John Quin, Mark R. Palmert, Eric J. Brown, J. McConnell, P. Pugsley, Paul Crawford, W. Dahms, Naina Sinha Gregory, M. E. Lackaye, Szilárd Kiss, R. Chan, Anton Orlin, Mark A. Rubin, David J. Brillon, V. Reppucci, T. Lee, M. Heinemann, Shu-Lin Chang, Brian Levy, Lois Jovanovič, M. Richardson, B. Bosco, A. Dwoskin, Robert Hanna, S. Barron, R. Keith Campbell, Arti Bhan, Davida Kruger, Jackie Jones, Paul Edwards, J. David Carey, Elizabeth M. Angus, Abraham Thomas, A. Galprin, Michael D. McLellan, Fred W. Whitehouse, R. Bergenstal, Mark W. Johnson, K. Gunyou, L. Thomas, J. Laechelt, Priscilla Hollander, M. Spencer, David M. Kendall, Robert Cuddihy, P. Callahan, S. List, John Parker Gott, Nathalie Rude, Beth A. Olson, M. Franz, G. Castle, Ruby Birk, J. Nelson, D. Freking, L. Gill, W. Mestrezat, Donnell D. Etzwiler, Kari Lock Morgan, Lloyd Paul Aiello, E. Golden, Paul G. Arrigg, V. Asuquo, Richard S. Beaser, L. Bestourous, Jerry D. Cavallerano, Robert W. Cavicchi, Om P. Ganda, Osama Hamdy, R. S. Kirby, T. Murtha, D. Schlossman, S Shah, George S. Sharuk, P. Silva, P. Silver, Margaret E. Stockman, Jennifer K. Sun, E. Weimann, Howard Wolpert, Lloyd M. Aiello, A. Jacobson, Lawrence I. Rand, J. Rosenzwieg, Mary Larkin, M. Christofi, K. Folino, John E. Godine, Peter Lou, Christine Stevens, Ellen Anderson, H. Bode, Stuart J. Brink, Chad Cornish, David Cros, Linda M. Delahanty, Andrea deManbey, C. Haggan, Jane Lynch, Charles McKitrick, Dennis K. Norman, Dirk F. Moore, Mei‐Sing Ong, Caitlin Taylor, D. Zimbler, Sheila E. Crowell, Stephanie A. Fritz, Kasper D. Hansen, C. Gauthier‐Kelly, F. John Service, Andrew J. Barkmeier, Louise Schmidt, Benjamin French, R. Woodwick, R. A. Rizza, Morey W. Haymond, John M. Pach, J. Mortenson, B. Zimmerman, Alexander R. Lucas, Robert C. Colligan, Louis M. Luttrell, Maria F. Lopes‐Virella, Susan Caulder, C. Pittman, Neha Patel, K. Lee, M. Nutaitis, Jyotika K. Fernandes, Kathie L. Hermayer, Soo Bin Kwon, Amy Blevins, Jeremy C. Parker, John A. Colwell, Daniel J. Lee, J. Soule, P. Lindsey, M. Bracey, A. Farr, S. Elsing, T. Thompson, J. Bayne Selby, Timothy J. Lyons, S. Yacoub‐Wasef, M. Szpiech, D. Wood, Ronald K. Mayfield, Mark E. Molitch, Daphne T. Adelman, S. Colson, Lee M. Jampol, Alice T. Lyon, Manjot K. Gill, Z. Strugula, L. Kaminski, Rukhsana G. Mirza, Evica Simjanoski, Donna H. Ryan, C. J. Johnson, Amisha Wallia, Senda Ajroud‐Driss, P. Astelford, N. Leloudes, Aria Degillio, B. Schaefer, Sunder Mudaliar, Gayle M. Lorenzi, Michael H. Goldbaum, Karen L. Jones, Martin R. Prince, Michael R. Swenson, Igor Grant, Rebecca G. Reed, R. Lyon, Orville Kolterman, M Giotta, Taylor L. Clark, Georgina Friedenberg, B. Vittetoe, John R. Kramer, Meg Bayless, Rodney Zeitler, Helmut G. Schrott, Nels C. Olson, L. Snetselaar, Robert P. Hoffman, John H. MacIndoe, T. A. Weingeist, C. Fountain, Ryan S. Miller, S. Johnsonbaugh, Marena Patronas, Maureen F. Carney, Susan R. Mendley, P. Salemi, R. Liss, M. Hebdon, Debra Counts, Thomas Donner, Jason Gordon, R Hemady, A. Avinoam Kowarski, Daniela Ostrowski, Scott M. Steidl, B.E. Jones, William H. Herman, C. L. Martin, Rodica Pop‐Busui, D. A. Greene, Martin Stevens, N. Burkhart, T. Sandford, J. Floyd, Nancy Flaherty, James G. Terry, Dara D. Koozekanani, Sandra R. Montezuma, N. Wimmergren, B. Rogness, M. Mech, T. Strand, Janet E. Olson, Laurie J. McKenzie, C. Kwong, F. C. Goetz, R. Warhol, Dean P. Hainsworth, D. Goldstein, Susan Hitt, Joseph Giangiacomo, David S. Schade, Janene L. Canady, Mark R. Burge, Arup Das, Robert B. Avery, Loren H. Ketai, J. E. Chapin, Michael Schlüter, Jonathan Rich, Carolyn Johannes, D. Hornbeck, Mark H. Schutta, P. A. Bourne, Alexander J. Brucker, Seth Braunstein, Stanley S. Schwartz, B. J. Maschak-Carey, L. Baker, Trevor J. Orchard, L. Cimino, Thomas J. Songer, Bernard H. Doft, Sara H. Olson, Dorothy J. Becker, Debra Rubinstein, Robert L. Bergren, J. Fruit, Rick Hyre, Catherine V. Palmer, N. Silvers, Louis A. Lobes, Pamela Rath, Paula Conrad, S. Yalamanchi, J. Wesche, M. Bratkowksi, S. Arslanian, Jeffrey S. Rinkoff, Joseph W. Warnicki, Denis Curtin, Dori Steinberg, G. Vagstad, R. Harris, L. Steranchak, J. Arch, Katherine Kelly, P. Ostrosaka, M. Guiliani, Misty Good, T. Williams, Kim Rose Olsen, Andrew Campbell, C. Shipe, Robin Conwit, David N. Finegold, M. Zaucha, Allan Drash, Alanna C. Morrison, John I. Malone, M.L. Bernal, Peter R. Pavan, N. Grove, Eitaro Tanaka, Donald C. McMillan, J. Vaccaro‐Kish, L. Babbione, H. Solc, Terry J. DeClue, Samuel Dagogo‐Jack, Catrin Wigley, Harriet Ricks, A. Kitabchi, Edward Chaum, Mary Beth Murphy, S. Moser, Dale R. Meyer, A. Iannacone, S. Yoser, Michael Bryer‐Ash, S. Schüßler, Helen Lambeth, Philip Raskin, Suzanne Strowig, Monica Ramirez Basco, S. Cercone, Annette Barnie, Robert G. Devenyi, Mark S. Mandelcorn, Michael H. Brent, S. Rogers, A. Gordon, N. Bakshi, Bruce A. Perkins, Laurie Tuason, F. Perdikaris, Rodney Ehrlich, Denis Daneman, Kusiel Perlman, Sarah E. Ferguson, Julie R. Palmer, R. Fahlstrom, Ian H. de Boer, James L. Kinyoun, Lois Van Ottingham, S. Catton, J S Ginsberg, Charlotte McDonald, J. Harth, M. Driscoll, Tom Sheidow, J. Mahon, C. Canny, David A. Nicolle, Pamela G. Colby, John Dupré, Irene Hramiak, N. W. Rodger, M. Jenner, Trish Smith, William F. Brown, Michael May, Joseph Hagan, Adhish Agarwal, T. Adkins, Rodney A. Lorenz, Stephen S. Feman, L. Survant, Neil H. White, L. Levandoski, G. Grand, M. Thomas, Dayle Hunt Joseph, Kevin J. Blinder, Gaurav K. Shah, Dean B. Burgess, Isaac Boniuk, Julio Santiago, William V. Tamborlane, P. Gatcomb, Kathleen Stoessel, P. Ramos, Kelvin C. Fong, Pilar N. Ossorio, J. Ahern, Lynne Meadema-Mayer, Cynthia A Beck, Kaleigh Farrell, Paul Gaston, R. R. Trail, John M. Lachin, Jye‐Yu C. Backlund, Ionut Bebu, L. Diminick, Xu Gao, Wei‐Chung Hsu, K. Klumpp, Hongxu Pan, Victoria R. Trapani, Paula McGee, Wujin Sun, S. Villavicencio, Kenton L. Anderson, L. Dews, Naji Younes, Brandy Rutledge, K. Chan, D Rosenberg, B. Petty, A. Determan, Danelle Kenny, C. C. Williams, Catherine C. Cowie, Carolyn Siebert, Michael W. Steffes, Valerie Arends, J. Bucksa, M. Nowicki, Blanche M. Chavers, Dena O’Leary, Joseph F. Polak, Anita Harrington, L. Funk, Richard S. Crow, B. Gloeb, S. Thomas, Christopher J. O’Donnell, Elsayed Z. Soliman, Z.M. Zhang, Y. Li, Colin Campbell, Lisa Keasler, S. Hensley, Jingzhou Hu, Margo Barr, T. Taylor, Ronald J. Prineas, Eva L. Feldman, James W. Albers, Phillip A. Low, C. Sommer, K. Nickander, T. Speigelberg, M. Pfiefer, M. Schumer, J. W. Farquhar, Christopher M. Ryan, D. Sandstrom, M. Geckle, Elisa Cupelli, Floyd Thoma, B. Burzuk, T. Woodfill, Ryan Danis, Barbara Blodi, David Lawrence, Hugh Wabers, Sapna Gangaputra, Sallie Neill, Matthias Burger, J. Dingledine, V. Gama, Rachael D. Sussman, Janet L. Davis, Larry D. Hubbard, Matthew J. Budoff, Sirous Darabian, Panteha Rezaeian, Nathan Wong, Marie Fox, Ronald J. Oudiz, L. Kim, Robert Detrano, Karen J. Cruickshanks, Dayna S. Dalton, K. Bainbridg, J. Lima, David A. Bluemke, Evrim Türkbey, Rob J. van der Geest, C. Liu, Ashkan A. Malayeri, Arun K. Jain, C. Miao, Harjit Chahal, R. Jarboe, Vincent M. Monnier, David R. Sell, Christopher Strauch, Stanley L. Hazen, Arthur G. Pratt, Wan‐Yee Tang, Rama Natarajan, L. Zhang, Zhuo Chen, Andrew D. Paterson, Andrew P. Boright, Shelley B. Bull, Lei Sun, Stephen W. Scherer, Alicia J. Jenkins, Richard L. Klein, Gabriel Virella, Ayad A. Jaffa, R. Carter, Julie A. Stoner, W. Timothy Garvey, Dan Lackland, M. Brabham, D L McGee, Danxia Zheng, John Maynard, Hunter Wessells, Aruna V. Sarma, R. Dunn, Sarah K. Holt, Jim Hotaling, Catherine Kim, Quentin Clemens, Jonathan D. Brown, Kevin T. McVary

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueDiabetes Care · 2017

Typearticle

Languageen

FieldMedicine

TopicDiabetes Management and Research

Canadian institutionsLunenfeld-Tanenbaum Research InstituteUniversity of TorontoMount Sinai Hospital

FundersNational Center for Advancing Translational SciencesNational Eye InstituteNational Institute of Diabetes and Digestive and Kidney DiseasesAbbott Diabetes CareRoche Diabetes CareEli Lilly and CompanyNiproInsulet CorporationNational Institute of Neurological Disorders and StrokeNovo NordiskSanofi

KeywordsMedicineDiabetes mellitusWeight gainQuartileInternal medicineType 2 diabetesEpidemiologyIncidence (geometry)Type 1 diabetesWeight changeRandomized controlled trialWeight lossSurgeryObesityEndocrinologyBody weightConfidence interval

DOI10.2337/dc16-2523

Abstract

fetched live from OpenAlex

OBJECTIVE Intensive treatment (INT) of type 1 diabetes reduces the incidence of cardiovascular disease (CVD) events compared with conventional treatment (CONV), but it also results in more weight gain. Our objective was to examine whether excessive weight gain from INT of type 1 diabetes is independently associated with subsequent CVD events. RESEARCH DESIGN AND METHODS Quartiles (Q) of weight gain in 1,213 participants aged 18 years and older at enrollment in the Diabetes Control and Complications Trial (DCCT) were determined within randomized treatment groups (INT vs. CONV) using change in BMI from baseline to the closeout DCCT visits. Effects of this weight gain on CVD risk factors and outcomes during an additional 20 years of observational follow-up were then determined. RESULTS The Q4 INT group experienced greater proportional weight gain (median change in BMI, 6.08 kg/m2), increases in CVD risk factors, and need for medications for hypertension and lipids compared with the Q1–3 INT and comparable CONV groups. Over a mean of 26 years of follow-up, the numbers of major and total CVD events were not statistically different in Q4 compared with Q1–3 of either the INT or CONV group. By year 14, however, the incident CVD event curve became significantly higher in the Q4 INT group than in the Q1–3 INT groups (P = 0.024) and was similar to that for the CONV group. CONCLUSIONS For the first 13 years after DCCT, INT for type 1 diabetes reduced macrovascular events compared with CONV, even when excessive weight gain occurred. After this, total CVD events significantly increased in the Q4 INT group, becoming equivalent to those in the CONV group. Longer follow-up is needed to determine whether this trend continues and results in more major CVD events.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002

metaresearch head score (Gemma)0.005

Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated

Candidate categoriesMeta-epidemiology (narrow)

Consensus categoriesnone

DomainCandidate signal: none · Consensus signal: none

Study designCandidate signal: Observational · Consensus signal: Observational

GenreCandidate signal: Empirical · Consensus signal: Empirical

Teacher disagreement score0.022

Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

Category	Codex	Gemma
Metaresearch	0.002	0.005
Meta-epidemiology (narrow)	0.000	0.000
Meta-epidemiology (broad)	0.002	0.001
Bibliometrics	0.000	0.000
Science and technology studies	0.000	0.001
Scholarly communication	0.000	0.000
Open science	0.001	0.000
Research integrity	0.000	0.000
Insufficient payload (model declined to judge)	0.000	0.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.079

GPT teacher head0.389

Teacher spread0.310 · how far apart the two teachers sit on this one work

Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Quick stats

Citations118

Published2017

Admission routes1

Has abstractyes

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