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Record W2770163198 · doi:10.2217/pgs-2017-0051

Validating a Research Ethnicity Questionnaire using Genomic Markers

2017· article· en· W2770163198 on OpenAlexafffund
Nuwan C. Hettige, Ali Bani‐Fatemi, Vincenzo De Luca

Bibliographic record

VenuePharmacogenomics · 2017
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsCanada Research ChairsUniversity of TorontoCentre for Addiction and Mental Health
FundersUniversity of Toronto
KeywordsPopulation stratificationEthnic groupGenetic genealogyConfoundingGenotypingGrandparentAncestry-informative markerPopulationPsychologyMedicineClinical psychologyBiologyGenotypeDevelopmental psychologyEnvironmental healthGeneticsAllele frequencySingle-nucleotide polymorphismInternal medicine

Abstract

fetched live from OpenAlex

AIM: Population stratification is a confounding factor in genetic association studies. Self-report measures, the most common method of collecting ethnicity, may be less reliable for psychiatric patients. This study aims to validate our research ethnicity questionnaire as a reliable measure of genetic ancestry. METHODS: The validity of our questionnaire was compared with genetic ancestry according to structured association tests and dimensional reduction methods. Our research tool was also compared with a standard multiple choice questionnaire. RESULTS: Our research questionnaire was highly consistent with genetic ancestry. The standard questionnaire demonstrated a greater degree of inconsistency in identifying ethnicity. CONCLUSION: Collecting information on the geographical ancestry of each individual's grandparents provides a more comprehensive view of ethnicity to prevent population stratification and wasted finances on genotyping.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.678
Threshold uncertainty score0.864

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.151
GPT teacher head0.448
Teacher spread0.297 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2017
Admission routes2
Has abstractyes

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