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Record W2770785706 · doi:10.1021/cen-09029-meetings

Bringing Materials Science To Pharma

2012· article· en· W2770785706 on OpenAlex
MICHAEL HURREY, B. Quinn

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueChemical & Engineering News · 2012
Typearticle
Languageen
FieldEnvironmental Science
TopicChemistry and Chemical Engineering
Canadian institutionsnot available
Fundersnot available
KeywordsCitationAltmetricsSocial mediaComputer scienceLibrary scienceInformation retrievalWorld Wide Web

Abstract

fetched live from OpenAlex

By paying insufficient attention to the physical, solid-state properties of drug compounds, the pharmaceutical industry has missed opportunities for new drugs and imposed untold costs on itself, according to a group of industry leaders. Drug companies can better carry out their core duty—creating new medicines—by drawing more rigorously on materials science and engineering and translating this fundamental science into pharmaceutical development, they say. To promote this goal, the group launched the M3 conference, named for “Molecules, Materials, Medicines.” The third M3 meeting took place on May 19–22 in Banff, Alberta. The group includes Örn Almarsson and Magali Hickey of Alkermes, Patrick Connelly and Michael (Mick) Hurrey of Vertex Pharmaceuticals, Drazen Ostovic of KO Pharm R&D, Matt Peterson of Amgen, and Elizabeth B. Vadas of InSciTech. For years, they advocated for earlier and more rigorous application of solid-state materials science in pharmaceutical R&D. They argued, both in their own workplaces and ...

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.011
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.214
Teacher spread0.207 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it