Interconnected Neural, Vascular, and Metabolic Dysfunction during Cortical Spreading Depression: A Mathematical Model
Bibliographic record
Abstract
Summary of model components Neuronal behavior determined by conductances, Na + /K + ATPaseATPase behavior governed by availability of oxygenOxygen delivery determined by blood flow and thus arterial diameterArterial diameter driven by extracellular [K + ]Extracellular [K + ] buffered by astrocytes, generated by neurons Effect of vascular parameters on CSD Duration of CSD for different vascular responses. Shown are CSD durations plotted against percent dilation b, constriction parameter a, (this parameter has the units of mM and is a measure of how rapidly the effective radius decreases as [K + ] changes) and oxygen coupling constant γ. Duration is defined by the length of time that potas-sium concentration is elevated to a level greater than 6 mM. Speed of CSD for different vascular responses. Increasing the constriction parameter a makes the vessel less sensitive to potassium, weakening the resulting constriction. The speed decreases as [K + ] increases from 30mM up tp 80mM, but increasing the amount of dilation by inreasing b seems to have a greater effect.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".