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Record W2773300519 · doi:10.15698/mic2017.12.605

VAMP8 mucin exocytosis attenuates intestinal pathogenesis by Entamoeba histolytica

2017· letter· en· W2773300519 on OpenAlexafffund
Steve Cornick, France Moreau, Herbert Y. Gaisano, Kris Chadee

Bibliographic record

VenueMicrobial Cell · 2017
Typeletter
Languageen
FieldMedicine
TopicAmoebic Infections and Treatments
Canadian institutionsUniversity of TorontoUniversity of Calgary
FundersNatural Sciences and Engineering Research Council of CanadaCrohn's and Colitis CanadaUniversity of Calgary
KeywordsSecretionMucusExocytosisBiologyCell biologyIntestinal mucosaEntamoeba histolyticaMicrobiologyMucinImmune systemGoblet cellIntestinal epitheliumImmunologyEpitheliumBiochemistryMedicine

Abstract

fetched live from OpenAlex

VAMP8 mucin exocytosis attenuates intestinal pathogenesis by Entamoeba histolytica – The colonic mucus barrier forms a bimodal layer consisting of an inner firmly adherent layer immediately above the epithelial cells and an outer less dense layer that is heavily colonized by commensal microbiota. Goblet cells continually replenish the mucus layer that is constantly eroded by luminal bacteria by producing and releasing the primary component of (...)

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0030.003
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.238
Teacher spread0.223 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2017
Admission routes2
Has abstractyes

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