Endogenous sodium pump inhibitors: common pathogenetic mechanisms of impaired glucose tolerance and preeclampsia
Bibliographic record
Abstract
Aim. Study of the influence of sodium chloride overconsumption by pregnant rats with induced diabetes mellitus on the synthesis of marinobufagenin and Na/K-ATPase activity. Methods. The study was performed on 72 female Sprague Dawley rats. Type 2 diabetes mellitus was induced by administration of 65 mg/kg streptozotocin on day 4 after birth. Increased intake of salt was achieved by replacement of drinking water with 1.8% sodium chloride solution on days 12 to 19 of pregnancy. Results. In intact rats, pregnancy was associated with a two-fold increase of marinobufagenin level in the blood and mild impairment of glucose tolerance. Pregnant rats with induced diabetes mellitus apart from fetal macrosomia exhibited greater impairment of glucose tolerance and higher levels of marinobufagenin compared to those in intact pregnant animals. Compared to healthy pregnant rats, salt supplementation for laboratory animals with diabetes was associated with an increase in systolic blood pressure, decreased fetal and placental weight, five-fold elevation of marinobufagenin excretion, and in 42% - with inhibition of Na/K-ATPase activity in erythrocytes. In nonpregnant rats, pre-treatment with anti-marinobufagenin antibodies produced an exaggerated increase of blood levels of glucose and insulin in oral glucose tolerance test. Conclusion. Marinobufagenin is an important factor of pathogenesis of both preeclampsia and diabetes mellitus, and regulation of glucose tolerance may be one of the physiological functions of endogenous cardiotonic steroids.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".